The Role of Acupoint Application of Herbal Medicine for Asthma: Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.
The Role of Acupoint Application of Herbal Medicine for Asthma: Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.
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DOI：
10.1155/2022/5589433
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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中药穴位贴敷在我国已得到广泛应用。目前，尚无AAHM与安慰剂治疗哮喘的系统评价。本系统评价旨在评估AAHM治疗哮喘的疗效。 从开始到2020年12月，在5个英文数据库和4个中文数据库中进行了检索。筛选了随机双盲安慰剂对照试验，包括评价常规药物治疗（RP）加AAHM与RP加安慰剂或AAHM与安慰剂的研究。采用科克伦偏倚风险评估工具和推荐分级评估、发展和评价（GRADE）分别评价方法学质量和证据质量。 本综述纳入了16项研究，涉及1，730名受试者。与安慰剂+RP相比，接受长期AAHM + RP的参与者显示哮喘生活质量问卷（AQLQ）改善，证据质量中等（MD 6.53分，95%CI 2.70至10.36）。低质量证据表明，与安慰剂+RP相比，AAHM + RP与FEV 1（%）改善相关，无论是长期还是短期使用（MD 11.80%，95%CI 2.84 - 20.76; MD 10.57%，95%CI 8.40 - 12.74;分别）。中等质量证据显示，与安慰剂相比，接受短期AAHM的参与者与较高的AQLQ评分（MD 6.57分，95% CI 3.76至9.38）和较低的急性加重频率（MD-1.84，95% CI -2.32至-1.36）相关。低质量证据还表明，与安慰剂相比，AAHM与FEV 1（L）改善相关，无论是长期还是短期使用（MD 0.35升，95% CI 0.03至0.67; MD 0.66升，95% CI 0.59至0.73;分别）。 中等质量的证据表明AAHM可以改善哮喘患者的生活质量，减少急性加重。AAHM在改善肺功能方面也显示出积极的作用，但由于质量不高，证据不确定。
Acupoint application of herbal medicine (AAHM) has been widely used in China. At present, there is no systematic review of AAHM versus placebo in the treatment of asthma. This systematic review aims to assess the efficacy of AAHM for asthma. Searches were conducted in five English databases and four Chinese databases from their inceptions until December 2020. Randomized double-blind placebo-controlled trials were screened, and included studies evaluated routine pharmacotherapy (RP) plus AAHM versus RP plus placebo or AAHM versus placebo. The Cochrane risk of bias tool and Grading of Recommendations Assessment, Development and Evaluation (GRADE) were performed to evaluate the methodological quality and quality of evidence separately. Sixteen studies involving 1,730 participants were included in this review. Compared with placebo plus RP, participants receiving long-term AAHM plus RP showed improvement in asthma quality of life questionnaire (AQLQ) with moderate-quality evidence (MD 6.53 points, 95% CI 2.70 to 10.36). Low-quality evidence indicated that AAHM plus RP was associated with improved FEV1 (%) compared with placebo plus RP, whether long- or short-term use (MD 11.80%, 95% CI 2.84 to 20.76; MD 10.57%, 95% CI 8.40 to 12.74; respectively). Moderate-quality evidence showed that participants receiving short-term AAHM were associated with a higher AQLQ score (MD 6.57 points, 95% CI 3.76 to 9.38) and a lower frequency of acute exacerbations (MD –1.84, 95% CI –2.32 to –1.36) compared with placebo. Low-quality evidence also indicated that AAHM was associated with improved FEV1 (L) compared with placebo, whether long- or short-term use (MD 0.35 litres, 95% CI 0.03 to 0.67; MD 0.66 litres, 95% CI 0.59 to 0.73; respectively). Moderate-quality evidence is promising that AAHM can improve the quality of life and reduce acute exacerbations in patients with asthma. AAHM also shows a positive role in improving lung function, but the evidence is so indefinite due to low quality.
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影响因子：
8
作者：
Akinbami, Lara J.;Moorman, Jeanne E.;Sondik, Edward J.
通讯作者：
Sondik, Edward J.
影响因子：
14.2
作者：
Nathan, RA;Sorkness, CA;Pendergraft, TB
通讯作者：
Pendergraft, TB
影响因子：
12.4
作者：
Papadopoulos NG;Arakawa H;Carlsen KH;Custovic A;Gern J;Lemanske R;Le Souef P;Mäkelä M;Roberts G;Wong G;Zar H;Akdis CA;Bacharier LB;Baraldi E;van Bever HP;de Blic J;Boner A;Burks W;Casale TB;Castro-Rodriguez JA;Chen YZ;El-Gamal YM;Everard ML;Frischer T;Geller M;Gereda J;Goh DY;Guilbert TW;Hedlin G;Heymann PW;Hong SJ;Hossny EM;Huang JL;Jackson DJ;de Jongste JC;Kalayci O;Aït-Khaled N;Kling S;Kuna P;Lau S;Ledford DK;Lee SI;Liu AH;Lockey RF;Lødrup-Carlsen K;Lötvall J;Morikawa A;Nieto A;Paramesh H;Pawankar R;Pohunek P;Pongracic J;Price D;Robertson C;Rosario N;Rossenwasser LJ;Sly PD;Stein R;Stick S;Szefler S;Taussig LM;Valovirta E;Vichyanond P;Wallace D;Weinberg E;Wennergren G;Wildhaber J;Zeiger RS
通讯作者：
Zeiger RS
DOI：
10.1081/clt-120004405
发表时间：
2002-01-01
期刊：
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY
影响因子：
--
作者：
Drew, AK;Whyte, IM;Myers, SP
通讯作者：
Myers, SP
影响因子：
1.6
作者：
Lee SH;Chang GT;Zhang X;Lee H
通讯作者：
Lee H