U-Shaped Association of Aspect Ratio and Single Intracranial Aneurysm Rupture in Chinese Patients: A Cross-Sectional Study.
U-Shaped Association of Aspect Ratio and Single Intracranial Aneurysm Rupture in Chinese Patients: A Cross-Sectional Study.
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DOI：
10.3389/fneur.2021.731129
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发表时间：
2021
影响因子：
3.4
通讯作者：
Wang XL
中科院分区：
文献类型：
--
作者：
Yin JH;Su SX;Zhang X;Bi YM;Duan CZ;Huang WM;Wang XL
背景资料：以往的研究分析了颅内动脉瘤破裂与动脉瘤纵横比（AR）的关系，但结果不确定且存在争议。因此，本研究旨在更详细地估计中国IA患者中AR与IA破裂之间的相关性。方法：采用横断面研究。我们回顾性收集了2010年1月至2017年11月期间1，588例患有单一IA的中国患者。检查诊断时AR与IA破裂之间的关系。协变量包括人口统计学数据、形态学参数、生活习惯、临床特征和合并症。二元逻辑回归和两段线性模型用于分析AR与IA破裂的独立关联。结果：AR与IA破裂呈U型关系。在1.08-1.99的AR范围内，AR每增加0.1个单位，IA破裂的患病率降低13%[比值比0.87，95%置信区间（CI）0.80-0.98]。相反，AR每增加0.1个单位，IA破裂的患病率增加约3%（比值比1.03，95% CI 1.01-1.06），AR范围为3.42-4.08。结论：AR与IA破裂之间的关系呈U形，AR为1.08-1.99时负相关，AR为3.42-4.08时正相关。
Background: Previous studies have analyzed the association of aspect ratio (AR) on the ruptured intracranial aneurysm (IA), but the findings are inconclusive and controversial. Therefore, the study aimed to derive a more detailed estimation of this association between AR and ruptured IA in Chinese IA patients. Methods: The present work was a cross-sectional study. We retrospectively collected 1,588 Chinese patients with a single IA from January 2010 to November 2017. The relationship was examined between AR at diagnosis and ruptured IA. Covariates included data of demographics, morphological parameters, lifestyle habits, clinical features, and comorbidities. Binary logistic regression and two-piecewise linear models were used to analyze independent associations of AR with ruptured IA. Results: The results suggest that the association between AR and IA rupture was U-shaped. In the AR range of 1.08–1.99, the prevalence of IA rupture was 13% lower for each 0.1-unit increment in AR [odds ratio 0.87, 95% confidence interval (CI) 0.80–0.98]. Conversely, for every 0.1-unit increase in AR, the prevalence of IA rupture increased by ~3% (odds ratio 1.03, 95% CI 1.01–1.06) in the AR range of 3.42–4.08. Conclusion: The relationship between AR and ruptured IA was U-shaped, with the negative association at AR of 1.08–1.99 and positive association at AR of 3.42–4.08.
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影响因子：
3.7
作者：
Kang H;Ji W;Qian Z;Li Y;Jiang C;Wu Z;Wen X;Xu W;Liu A
通讯作者：
Liu A
分析形态学参数以区分前交通动脉瘤中的破裂状态。
影响因子：
3.7
作者：
Lin N;Ho A;Charoenvimolphan N;Frerichs KU;Day AL;Du R
通讯作者：
Du R
后交通动脉瘤破裂状态的形态学和血流动力学鉴别因素
影响因子：
3.7
作者：
Lv N;Wang C;Karmonik C;Fang Y;Xu J;Yu Y;Cao W;Liu J;Huang Q
通讯作者：
Huang Q
影响因子：
4.8
作者：
Elsharkawy, Ahmed;Lehecka, Martin;Hernesniemi, Juha
通讯作者：
Hernesniemi, Juha
未破裂后交通动脉瘤伴动眼神经麻痹的血流动力学和形态学特征。
影响因子：
4.1
作者：
Lv, Nan;Yu, Ying;Huang, Qinghai
通讯作者：
Huang, Qinghai