Resolution of inflammation: state of the art, definitions and terms.
Resolution of inflammation: state of the art, definitions and terms.
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DOI：
10.1096/fj.06-7227rev
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发表时间：
2007-02
期刊：
影响因子：
--
通讯作者：
Wallace JL
中科院分区：
文献类型：
--
作者：
Serhan CN;Brain SD;Buckley CD;Gilroy DW;Haslett C;O'Neill LA;Perretti M;Rossi AG;Wallace JL
最近一次关于控制急性炎症的焦点会议于 2006 年 4 月 27 日至 28 日在伦敦举行，会议由 D.W.吉尔罗伊和 S.D.英国药理学会的大脑。我们在会议上得出的结论是，需要一份共识报告来解决这一新兴领域的快速进展，并详细说明急性炎症消退的具体研究如何为新型抗炎治疗提供线索，并定义当今所理解的组织内消退过程中感兴趣的术语和关键组成部分。炎症反应可以保护身体免受感染和损伤，但其本身可能会失调，从而对宿主产生有害后果。现在很明显，防御反应期间激活的内源生化途径可以反调节炎症并促进消退。因此，消退是一个主动而非被动的过程，正如人们曾经认为的那样，这现在有望为基于内源性消退激动剂的炎症相关疾病的治疗提供新的方法。
A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti-inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today. The inflammatory response protects the body against infection and injury but can itself become dysregulated with deleterious consequences to the host. It is now evident that endogenous biochemical pathways activated during defense reactions can counter-regulate inflammation and promote resolution. Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation-associated diseases based on endogenous agonists of resolution.
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影响因子：
82.9
作者：
Gilroy, DW;Colville-Nash, PR;Willoughby, DA
通讯作者：
Willoughby, DA
影响因子：
16.8
作者：
Buckley, CD;Pilling, D;Salmon, M
通讯作者：
Salmon, M
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
4.4
作者：
Giles, KM;Ross, K;Dransfield, I
通讯作者：
Dransfield, I
影响因子：
32.4
作者：
Agostini, L;Martinon, F;Tschopp, J
通讯作者：
Tschopp, J