Minority report: the intestinal mycobiota in systemic infections.

Minority report: the intestinal mycobiota in systemic infections.
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少数族裔报告:全身感染中的肠道菌菌群。

DOI:
10.1016/j.mib.2020.05.004
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发表时间:
2020-08
影响因子:
5.4
通讯作者:
Zhai B
Zhai B
中科院分区:
生物学2区
文献类型:
--
作者:
Rolling T;Hohl TM;Zhai B

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与细菌相比,真菌通常在肠道微生物群中表现出较低的丰度和较高的时间波动性。微生物群(真菌生物群)中真菌的分析面临着最初为分析细菌而开发的工具的技术限制。肠道菌群的生态失调状态通常与健康细菌微生物群的破坏有关,其特征在于特定真菌分类群的过度生长(占优势)和多样性的丧失。念珠菌属的肠道优势已被证明是念珠菌属血流感染的主要来源。真菌生态失调也与非真菌感染的发展和治疗反应有关,例如艰难梭菌结肠炎和HIV。需要进一步的研究来确定肠道菌群对人类真菌和非真菌感染的贡献。
Compared to bacteria, fungi often exhibit a lower abundance and a higher temporal volatility in the intestinal microbiota. Analysis of fungi in the microbiota (mycobiota) faces technical limitations with tools that were originally developed for analyzing bacteria. Dysbiotic states of the intestinal mycobiota, often associated with disruption of the healthy bacterial microbiota, are characterized by overgrowth (domination) of specific fungal taxa and loss of diversity. Intestinal domination by Candida species has been shown to be a major source of Candida bloodstream infections. Fungal dysbiosis is also linked to the development and treatment response in non-fungal infections, for example Clostridioides difficile colitis and HIV. Further research is needed to define the contribution of intestinal mycobiota to human fungal and non-fungal infections.
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