Integrating electrophysiological and anatomical experimental data to create a large-scale model that simulates a delayed match-to-sample human brain imaging study.
Integrating electrophysiological and anatomical experimental data to create a large-scale model that simulates a delayed match-to-sample human brain imaging study.
复制标题
整合电生理学和解剖学实验数据，创建一个大规模模型，模拟延迟匹配样本人脑成像研究。
作者：
M. Tagamets;Barry Horwitz
我们提出了一个模型，该模型汇集了来自解剖学、电生理学和成像实验的实验证据，以便更好地理解使用正电子断层扫描（PET）和功能磁共振成像（fMRI）进行人类成像研究的神经基质。首先，我们定义一个简单的局部电路，反映局部连接在产生 PET 和 fMRI 数据中所起的主要作用，这些数据被认为主要反映突触活动。其次，为了解释典型成像实验过程中不同行为的作用，我们提出了一种可以执行延迟匹配样本任务的本地电路。该回路的各个元件的行为非常类似于在猴子的类似任务中在前额皮质中发现的神经元。仅当存在刺激时，一个亚群才会选择性地做出反应。两个不同的群体显示出已确定的两种类型的延迟期活动，一种在提示期和延迟期都具有高活性，另一种仅在延迟期期间活动增加。最后，只有当第二个刺激与第一个刺激匹配时，亚群才会表现出简短的反应，从而调节刺激是否匹配的决定。我们表明，除了执行任务之外，模型的综合突触活动与实验 PET 数据相似。
We propose a model that draws together experimental evidence from anatomical, electrophysiological and imaging experiments in order to understand better the neural substrate of human imaging studies using positron electron tomography (PET) and functional magnetic resonance imaging (fMRI). First, we define a simple local circuit that reflects the major role that local connectivity plays in producing PET and fMRI data, which are thought to mainly reflect synaptic activity. Second, in order to account for the role of varying behaviors during the course of a typical imaging experiment, we propose a local circuit that can perform a delayed match-to-sample task. The elements of this circuit behave very much like neurons that have been found in the prefrontal cortex during similar tasks in monkeys. One subpopulation responds selectively only when stimuli are present. Two different populations show the two types of delay-period activity that have been identified, one with high activity both during the cue and the delay period, the other with a rise during the delay period only. Last, a subpopulation shows a brief response only if the second stimulus matches the first, thus mediating the decision about whether the stimuli match. We show that in addition to performing the task, the integrated summed synaptic activities of the model are similar to experimental PET data.
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影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
影响因子：
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作者：
FUNAHASHI, S;BRUCE, CJ;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS
影响因子：
56.9
作者：
GALLANT, JL;BRAUN, J;VANESSEN, DC
通讯作者：
VANESSEN, DC
影响因子：
56.9
作者：
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通讯作者：
RAICHLE, ME
影响因子：
56.9
作者：
SERENO, MI;DALE, AM;TOOTELL, RBH
通讯作者：
TOOTELL, RBH