Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study.
Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study.
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DOI：
10.1016/j.mri.2020.04.002
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发表时间：
2020-07
影响因子：
2.5
通讯作者：
Yu JJ
中科院分区：
文献类型：
--
作者：
Barnett BR;Casey CP;Torres-Velázquez M;Rowley PA;Yu JJ
对精神疾病的神经成像研究揭示了广泛的结构和功能障碍，这些障碍部分归因于支撑这些疾病的复杂遗传异质性。与对照人群相比，在临床前遗传模型和患者中都发现了这些扰动，但最近的工作也证明了几种精神疾病在遗传、分子和结构上趋同的有力证据。我们用弥散张量成像和轴突定向弥散和密度成像技术探索了ASD(Fmr1，NRXN1，Pten)和精神分裂症(DISC1，SVΔ2)临床前遗传模型与年龄和性别匹配的对照动物在神经微结构上的潜在相似性。我们的发现表明，通过基于区域和基于感兴趣区域的分析，这四个遗传模型在大脑微结构上的趋同，这继续支持对精神疾病中汇聚的神经微结构的新兴理解。
Neuroimaging studies of psychiatric illness have revealed a broad spectrum of structural and functional perturbations that have been attributed in part to the complex genetic heterogeneity underpinning these disorders. These perturbations have been identified in both preclinical genetic models and in patients when compared to control populations, but recent work has also demonstrated strong evidence for genetic, molecular, and structural convergence of several psychiatric diseases. We explored potential similarities in neural microstructure in preclinical genetic models of ASD (Fmr1, Nrxn1, Pten) and schizophrenia (Disc1 svΔ2) and in age- and sex-matched control animals with diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). Our findings demonstrate a convergence in brain microstructure across these four genetic models with both tract-based and region-of-interest based analyses, which continues to buttress an emerging understanding of converging neural microstructure in psychiatric disease.
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影响因子：
10.6
作者：
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通讯作者：
Anticevic A
影响因子：
6.8
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Nöthen MM
影响因子：
12.3
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影响因子：
11
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Sawa A