PPARα/γ-Independent Effects of PPARα/γ Ligands on Cysteinyl Leukotriene Production in Mast Cells
PPARα/γ-Independent Effects of PPARα/γ Ligands on Cysteinyl Leukotriene Production in Mast Cells
复制标题
PPARα/γ 配体对肥大细胞中半胱氨酰白三烯产生的 PPARα/γ 独立影响
作者：
M. Yamashita
过氧化物酶体增殖物激活受体 (PPAR) α 配体（Wy-14,643 和非诺贝特）和 PPARγ 配体（曲格列酮和西格列酮）抑制免疫球蛋白 E 处理的肥大细胞中抗原诱导的半胱氨酰白三烯产生。这些配体对半胱氨酰白三烯产生的抑制作用相当强，几乎与抗哮喘化合物齐留通相当。为了开发抗哮喘药物的新用途，应阐明这些化合物的药理学靶点。使用 PPARα 敲除小鼠骨髓来源的肥大细胞和 PPARγ 药理学抑制剂进行的实验表明，这些配体的抑制作用独立于 PPAR α 和 γ。本综述讨论了这些药物对半胱氨酰白三烯产生的非 PPAR 依赖性抑制机制。
Peroxisome proliferator-activated receptor (PPAR) α ligands (Wy-14,643, and fenofibrate) and PPARγ ligands (troglitazone and ciglitazone) inhibit antigen-induced cysteinyl leukotriene production in immunoglobulin E-treated mast cells. The inhibitory effect of these ligands on cysteinyl leukotriene production is quite strong and is almost equivalent to that of the anti-asthma compound zileuton. To develop new aspects for anti-asthma drugs the pharmacological target of these compounds should be clarified. Experiments with bone-marrow-derived mast cells from PPARα knockout mice and pharmacological inhibitors of PPARγ suggest that the inhibitory effects of these ligands are independent of PPARs α and γ. The mechanisms of the PPAR-independent inhibition by these agents on cysteinyl leukotriene production are discussed in this review.
过氧化物酶体增殖物激活受体α不依赖的过氧化物酶体增殖。
影响因子：
3.1
作者：
Zhang,Xiuguo;Tanaka,Naoki;Nakajima,Takero;Kamijo,Yuji;Gonzalez,FrankJ;Aoyama,Toshifumi
通讯作者：
Aoyama,Toshifumi
白三烯的代谢。
影响因子：
4.3
作者：
Hammarström,S;Orning,L;Bernström,K
通讯作者：
Bernström,K