Propranolol, a β-adrenergic antagonist, attenuates the decrease in trabecular bone mass in high calorie diet fed growing mice.
Propranolol, a β-adrenergic antagonist, attenuates the decrease in trabecular bone mass in high calorie diet fed growing mice.
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DOI：
10.5483/bmbrep.2014.47.9.265
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发表时间：
2014-09
期刊：
影响因子：
3.8
通讯作者：
Baek JH
中科院分区：
文献类型：
--
作者：
Baek K;Hwang HR;Park HJ;Kwon A;Qadir AS;Baek JH
我们研究了高卡路里和低卡路里饮食对骨骼完整性的影响，以及β肾上腺素能拮抗剂(BB)是否减轻了由饮食卡路里改变引起的骨丢失。6周龄雄性C57BL/6小鼠随机分为对照组(CON)、高热量饲料(HIGH)和低热量饲料(Low)组。在每一组饮食中，小鼠接受β肾上腺素能拮抗剂VEH或心得安的治疗。在12周内，β阻断减轻了高卡路里饮食引起的体重和脂肪量增加。HIGHVEH和LOWVEH组小鼠股骨骨小梁密度和骨髓细胞成骨标志物基因的表达水平均降低，BB仅在高血糖组显著减轻这种下降。综上所述，在生长期小鼠中，低卡路里饮食引起的骨丢失幅度大于高卡路里饮食引起的骨丢失，β阻断减轻了高卡路里饮食引起的骨丢失。[BMB报告2014；47(9)：506-511]
We investigated the effects of high calorie and low calorie diets on skeletal integrity, and whether β-adrenergic blockade (BB) attenuates bone loss induced by dietary calorie alteration. Male 6-week-old C57BL/6 mice were assigned to either an ad-lib fed control diet (CON), a high calorie diet (HIGH), or a low calorie diet (LOW) group. In each diet group, mice were treated with either vehicle (VEH) or propranolol, a β-adrenergic antagonist. Over 12-weeks, β-blockade mitigated body weight and fat mass increases induced by the high calorie diet. Femoral trabecular bone mineral density and the expression levels of osteogenic marker genes in bone marrow cells were reduced in HIGHVEH and LOWVEH mice, and BB significantly attenuated this decline only in HIGH mice. In summary, the magnitude of bone loss induced by low calorie diet was greater than that caused by high calorie diet in growing mice, and β-blockade mitigated high calorie diet-induced bone loss. [BMB Reports 2014; 47(9): 506-511]
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