Endocrine and ovulatory responses of the gilt to exogenous gonadotropins and estradiol during sexual maturation.
Endocrine and ovulatory responses of the gilt to exogenous gonadotropins and estradiol during sexual maturation.
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性成熟过程中后备母猪对外源性促性腺激素和雌二醇的内分泌和排卵反应。
DOI：
10.1095/biolreprod30.2.289
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发表时间：
1984
影响因子：
3.6
通讯作者：
Dziuk,PJ
中科院分区：
文献类型：
--
作者：
Dial,GD;Dial,OK;Wilkinson,RS;Dziuk,PJ
本文研究了外源性雌二醇和促性腺激素对青春期前后备母猪内分泌和排卵的影响。研究1：用妊娠母马血清促性腺激素（PMSG）或生理盐水（SAL）给190日龄的未成熟母猪注射s.c.。注射PMSG后，循环雌二醇-17β(E2)水平升高。这种增加之后，黄体生成素（LH）激增，发情，黄体酮（P4）水平上升，排卵。服用SAL的后备母猪没有E2、LH或P4水平升高，也没有排卵。在研究二中，165日龄的青春期前后备母猪用不同剂量的PMSG处理。PMSG剂量与E2峰值水平呈正相关（r= 0.83， P< 0.001）， PMSG剂量与黄体数量呈正相关（r= 0.96， P< 0.001）。在研究3中，母猪在70 ~ 190日龄时分别用雌二醇苯甲酸酯（EB）、PMSG或玉米油加生理盐水（CO/SAL）处理，然后在72 ~ 96小时内用人绒毛膜促性腺激素（hCG）或SAL处理。所有在100 ~ 175日龄接受EB治疗的后备母猪大约每隔24小时出现两次LH高峰。在70天和190天对EB有反应的后备母猪只有一次LH激增。100日龄或以上的后备母猪对PMSG有单次或两次LH反应。在100日龄或更大的后备母猪中观察到对治疗有反应的排卵，但在70日龄时没有。从这些研究中得出的结论是：1)pmsg诱导的排卵之前，循环中e2水平增加，在一些后备母猪中，LH激增；2)青春期前后备母猪能够在70至190天内对外源性内分泌刺激产生单次或多次LH激增的反应，但直到100日龄才会对外源性促性腺激素产生反应。
Three studies were conducted to investigate the endocrine and ovulatory responses of the prepubertal gilt to exogenous estradiol and gonadotropins. In Study One, prepubertal gilts of 190 days of age were injected s.c. with pregnant mare’s serum gonadotropin (PMSG) or physiological saline (SAL). Following PMSG injection, circulating levels of estradiol-17β(E2) increased. This increase was followed by a surge of luteinizing hormone (LH), estrus, a rise in progesterone (P4) levels, and ovulation. None of the gilts given SAL had increased levels of E2, LH or P4, and none ovulated. In Study Two, prepubertal gilts of 165 days of age were treated with varying doses of PMSG. A positive correlation was observed between dose of PMSG and peak levels of E2(r= 0.83, P< 0.001) and between dose of PMSG and number of corpora lutea (r= 0.96, P< 0.001). In Study Three, gilts were treated at ages of 70 to 190 days with estradiol benzoate (EB), PMSG, or corn oil plus saline (CO/SAL) followed in 72 to 96 h by human chorionic gonadotropin (hCG) or SAL. All gilts treated with EB at 100 to 175 days of age had two surges of LH at an approximately 24-h interval. Gilts responding to EB at 70 and 190 days had only one surge of LH. Gilts of 100 days of age or older responded to PMSG with a single surge or two surges of LH. Ovulation in response to treatment was observed in gilts of 100 days of age or greater but not at 70 days. The conclusions drawn from these studies are that1) PMSG-induced ovulation is preceded by an increase in circulating levels of E2and in some gilts by a surge of LH, and2) prepubertal gilts are able to respond to exogenous endocrine stimulation with either a single surge or multiple surges of LH at 70 to 190 days but are unable to ovulate in response to exogenous gonadotropins until 100 days of age.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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