Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer.
Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer.
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DOI：
10.1186/bcr43
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Slingerland J
中科院分区：
文献类型：
--
作者：
Donovan J;Slingerland J
对细胞外信号的反应性改变和细胞周期失调是癌症的标志。细胞周期是由细胞周期蛋白依赖性激酶（cdks）整合有丝分裂和生长抑制信号。转化生长因子（TGF）-β通过诱导或激活cdk抑制剂以及通过抑制cdk激活所需的因子来介导G1期细胞周期停滞。综述了TGF-β导致细胞周期阻滞的机制。TGF-β生长抑制作用的丧失发生在乳腺细胞转化的早期，并可能导致乳腺癌进展。许多不同水平的细胞周期效应物的失调可能导致TGF-β引起的G1期阻滞的丧失。阐明乳腺癌中的这些通路可能最终导致这种疾病的新的和更有效的治疗方法。
Altered responsiveness to extracellular signals and cell cycle dysregulation are hallmarks of cancer. The cell cycle is governed by cyclin-dependent kinases (cdks) that integrate mitogenic and growth inhibitory signals. Transforming growth factor (TGF)-β mediates G1 cell cycle arrest by inducing or activating cdk inhibitors, and by inhibiting factors required for cdk activation. Mechanisms that lead to cell cycle arrest by TGF-β are reviewed. Loss of growth inhibition by TGF-β occurs early in breast cell transformation, and may contribute to breast cancer progression. Dysregulation of cell cycle effectors at many different levels may contribute to loss of G1 arrest by TGF-β. Elucidation of these pathways in breast cancer may ultimately lead to novel and more effective treatments for this disease.
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影响因子：
14.5
作者：
ADAMS, PD;KAELIN, WG
通讯作者：
KAELIN, WG
DOI：
10.1073/pnas.92.8.3239
发表时间：
1995-04-11
影响因子：
11.1
作者：
ALEXANDROW, MG;KAWABATA, M;MOSES, HL
通讯作者：
MOSES, HL
影响因子：
5.3
作者：
COFFEY, RJ;BASCOM, CC;MOSES, HL
通讯作者：
MOSES, HL
影响因子：
11.4
作者：
Bouchard, C;Thieke, K;Eilers, M
通讯作者：
Eilers, M
影响因子：
5.3
作者：
Aktas, H;Cai, H;Cooper, GM
通讯作者：
Cooper, GM