Catestatin: a multifunctional peptide from chromogranin A.
Catestatin: a multifunctional peptide from chromogranin A.
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DOI：
10.1016/j.regpep.2010.01.006
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发表时间：
2010-06-08
影响因子：
--
通讯作者：
O'Connor, Daniel T.
中科院分区：
文献类型：
--
作者：
Mahata, Sushil K.;Mahata, Manjula;Fung, Maple M.;O'Connor, Daniel T.
关键词：
In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA]344-364: RSMRLSFRARGYGFRGPGLQL; human CHGA352-372: SSMKLSFRARGYGFRGPGPQL), which is a potent inhibitor of nicotinic cholinergic-stimulated catecholamine secretion. CST shows characteristic inhibitory effects on nicotinic cationic (Na+, Ca2+) signal transduction, which are specific to the neuronal nicotinic receptor. Utilizing systematic polymorphism discovery at the human CHGA locus we discovered three human variants of CST: G364S, P370L, and R374Q that showed differential potencies towards inhibition of catecholamine secretion. In humans, CHGA is elevated and its processing to CST is diminished in hypertension. Diminished CST is observed not only in hypertensive individuals but also early-normotensive offspring of patients with hypertension, suggesting that an early deficiency of CST might play a pathogenic role in the subsequent development of the disease. Consistent with human findings, prevention of endogenous CST expression by targeted ablation (knockout) of the mouse Chga locus (Chga-KO) resulted in severe hypertension that can be “rescued” specifically by replacement of the CST peptide. CST acts directly on the heart to inhibit the inotropic and lusitropic properties of the rodent heart and also acts as a potent vasodilator in rat and human. While the G364S CST variant caused profound changes in human autonomic activity and seemed to reduce risk of developing hypertension, CST replacement rescued Chga-KO mice from dampened baroreflex sensitivity. In addition, CST has been shown to induce chemotaxis and acts as an antimicrobial as well as an antimalarial peptide. The present review summarizes these multiple actions of CST.
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DOI：
10.1111/j.1748-1716.1968.tb03851.x
发表时间：
1968-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
AARS, H
通讯作者：
AARS, H
影响因子：
5.5
作者：
GUO, X;WAKADE, AR
通讯作者：
WAKADE, AR
影响因子：
4.8
作者：
Angelone, Tommaso;Quintieri, Anna Maria;Cerra, Maria Carmela
通讯作者：
Cerra, Maria Carmela
影响因子：
4.8
作者：
Ghosh, JK;Shaool, D;Mor, A
通讯作者：
Mor, A
影响因子：
3.1
作者：
GWADZ, RW;KASLOW, D;MILLER, LH
通讯作者：
MILLER, LH