A novel method for multifactorial bio-chemical experiments design based on combinational design theory.
A novel method for multifactorial bio-chemical experiments design based on combinational design theory.
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基于组合设计理论的多因素生化实验设计新方法
DOI:
10.1371/journal.pone.0186853
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发表时间:
2017
期刊:
影响因子:
3.7
通讯作者:
Zheng P
中科院分区:
文献类型:
--
作者:
Wang X;Sun B;Liu B;Fu Y;Zheng P
Experimental design focuses on describing or explaining the multifactorial interactions that are hypothesized to reflect the variation. The design introduces conditions that may directly affect the variation, where particular conditions are purposely selected for observation. Combinatorial design theory deals with the existence, construction and properties of systems of finite sets whose arrangements satisfy generalized concepts of balance and/or symmetry. In this work, borrowing the concept of “balance” in combinatorial design theory, a novel method for multifactorial bio-chemical experiments design is proposed, where balanced templates in combinational design are used to select the conditions for observation. Balanced experimental data that covers all the influencing factors of experiments can be obtianed for further processing, such as training set for machine learning models. Finally, a software based on the proposed method is developed for designing experiments with covering influencing factors a certain number of times.
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影响因子:
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作者:
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通讯作者:
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DOI:
10.1109/tnnls.2014.2342533
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