Serotonergic 5-HT(1A) receptor agonist (8-OH-DPAT) ameliorates impaired micturition reflexes in a chronic ventral root avulsion model of incomplete cauda equina/conus medullaris injury.
Serotonergic 5-HT(1A) receptor agonist (8-OH-DPAT) ameliorates impaired micturition reflexes in a chronic ventral root avulsion model of incomplete cauda equina/conus medullaris injury.
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DOI：
10.1016/j.expneurol.2012.10.015
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发表时间：
2013-01
影响因子：
5.3
通讯作者：
Havton LA
中科院分区：
文献类型：
--
作者：
Chang HH;Havton LA
胸腰椎创伤通常会导致马尾和脊髓腰骶部分受伤。可能会出现完全损伤综合征和部分损伤综合征。在这里，我们测试了以下假设：血清素调节可能会改善马尾/髓圆锥不完全损伤后的排尿功能。为此，我们在大鼠中使用单侧 L5-S2 腹根撕脱 (VRA) 损伤模型来模拟马尾和髓圆锥的部分损伤。与假手术系列相比，全面的尿动力学研究表明，VRA 损伤后 12 周时排尿效率显着降低。详细的膀胱测压图研究表明，损伤引起的膀胱峰值压力降低表明收缩特性降低。并发尿道外括约肌 (EUS) 肌电图显示与消除阶段相关的爆发期缩短和静默期延长。接下来，在单侧 L5-S2 VRA 损伤后 12 周，静脉注射 5-HT1A 受体激动剂 8-羟基-2-(二正丙氨基)-四氢萘 (8-OH-DPAT)。 8-OH-DPAT (0.3-1.0 mg/kg) 显着提高了排尿效率和最大膀胱内压力。 8-OH-DPAT还增强了EUS强直和爆发活动的幅度以及EUS爆发期间EUS爆发和静默期的持续时间。结果表明，8-OH-DPAT 可提高单侧 VRA 损伤大鼠的排尿效率并增强 EUS 破裂。我们得出的结论是，在实验研究中，5-HT1A 受体的血清素能调节可能代表了改善马尾/圆锥不完全损伤后下尿路功能的新策略。
Trauma to the thoracolumbar spine commonly results in injuries to the cauda equina and the lumbosacral portion of the spinal cord. Both complete and partial injury syndromes may follow. Here, we tested the hypothesis that serotonergic modulation may improve voiding function after an incomplete cauda equina/conus medullaris injury. For this purpose, we used a unilateral L5-S2 ventral root avulsion (VRA) injury model in the rat to mimic a partial lesion to the cauda equina and conus medullaris. Compared to a sham-operated series, comprehensive urodynamic studies demonstrated a markedly reduced voiding efficiency at 12 weeks after the VRA injury. Detailed cystometrogram studies showed injury-induced decreased peak bladder pressures indicative of reduced contractile properties. Concurrent external urethral sphincter (EUS) electromyography demonstrated shortened burst and prolonged silent periods associated with the elimination phase. Next, a 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), was administered intravenously at 12 weeks after the unilateral L5-S2 VRA injury. Both voiding efficiency and maximum intravesical pressure were significantly improved by 8-OH-DPAT (0.3-1.0 mg/kg). 8-OH-DPAT also enhanced the amplitude of EUS tonic and bursting activity as well as duration of EUS bursting and silent period during EUS bursting. The results indicate that 8-OH-DPAT improves voiding efficiency and enhances EUS bursting in rats with unilateral VRA injury. We conclude that serotonergic modulation of the 5-HT1A receptor may represent a new strategy to improve lower urinary tract function after incomplete cauda equina/conus medullaris injuries in experimental studies.
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影响因子：
2
作者：
Gu, Baojun;Wu, Gang;Andersson, Karl-Erik
通讯作者：
Andersson, Karl-Erik
DOI：
10.1016/j.juro.2011.03.035
发表时间：
2011-07
期刊：
The Journal of urology
影响因子：
--
作者：
Cheng CL;de Groat WC
通讯作者：
de Groat WC
DOI：
10.1152/ajpregu.00270.2007
发表时间：
2008-02-01
影响因子：
2.8
作者：
Peng, Chih-Wei;Chen, Jia-Jin Jason;Grill, Warren M.
通讯作者：
Grill, Warren M.
DOI：
10.1152/ajpregu.00780.2005
发表时间：
2006-07-01
影响因子：
2.8
作者：
Chang, Hui-Yi;Cheng, Chen-Li;de Groat, William C.
通讯作者：
de Groat, William C.
DOI：
10.1152/ajpregu.2001.280.5.r1407
发表时间：
2001-05-01
影响因子：
2.8
作者：
Kakizaki, H;Yoshiyama, M;De Groat, WC
通讯作者：
De Groat, WC