COPB2 suppresses cell proliferation and induces cell cycle arrest in human colon cancer by regulating cell cycle-related proteins.
COPB2 suppresses cell proliferation and induces cell cycle arrest in human colon cancer by regulating cell cycle-related proteins.
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COPB2通过调节细胞周期相关蛋白抑制细胞增殖并诱导人结肠癌细胞周期停滞
DOI：
10.3892/etm.2017.5506
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发表时间：
2018-01
影响因子：
2.7
通讯作者：
Li M
中科院分区：
文献类型：
--
作者：
Wang Y;Chai Z;Wang M;Jin Y;Yang A;Li M
Coat proteins (COPs), including the major types clathrin, COPI and COPII, play a considerable role in intracellular transport by initiating the formation of transport vesicles. Coatomer protein complex subunit β2 (COPB2) is one of the seven subunits that make up a COPI complex. In the present study, we found that COPB2 was highly expressed in human colon cancer specimens. However, to date, there have been no reports describing the functions of COPB2 in human colon cancer cells. In this study, we analyzed the functions of COPB2 in the proliferation and cell cycle arrest of human RKO and HCT116 colon cancer cells by using lentivirus-mediated RNAi infection. Our results demonstrated that the silencing of COPB2 in vitro could inhibit the proliferation and colony formation abilities of RKO and HCT116 cells. Furthermore, measurement of cell cycle distribution indicated that the downregulation of COPB2 could induce G0/G1 or S phase cell cycle arrest by regulating cell cycle-related proteins. In conclusion, our results suggest that COPB2 plays a key role in the proliferation and cell cycle progression of human RKO and HCT116 colon cancer cells, thus indicating that COPB2 might be a potential therapeutic target for the treatment of human colon cancer.
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影响因子：
64.8
作者：
ORCI, L;PALMER, DJ;ROTHMAN, JE
通讯作者：
ROTHMAN, JE
Zeta-cop是涂层囊泡组件所必需的。
影响因子：
7.8
作者：
Kuge, O;Hara-Kuge, S;Orci, L;Ravazzola, M;Amherdt, M;Tanigawa, G;Wieland, F T;Rothman, J E
通讯作者：
Rothman, J E
影响因子：
--
作者：
Bie CQ;Liu XY;Cao MR;Huang QY;Tang HJ;Wang M;Cao GL;Yi TZ;Wu SL;Xu WJ;Tang SH
通讯作者：
Tang SH
影响因子：
11.4
作者：
STENBECK, G;HARTER, C;WIELAND, FT
通讯作者：
WIELAND, FT
DOI：
10.1126/science.1235122
发表时间：
2013-03-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Vogelstein B;Papadopoulos N;Velculescu VE;Zhou S;Diaz LA Jr;Kinzler KW
通讯作者：
Kinzler KW