Collagen-like peptides and peptide-polymer conjugates in the design of assembled materials.
Collagen-like peptides and peptide-polymer conjugates in the design of assembled materials.
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DOI：
10.1016/j.eurpolymj.2013.05.013
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发表时间：
2013-10
影响因子：
6
通讯作者：
Kiick, Kristi L.
中科院分区：
文献类型：
--
作者：
Luo, Tianzhi;Kiick, Kristi L.
胶原蛋白是哺乳动物体内含量最丰富的蛋白质，在新材料的设计中了解和控制胶原蛋白的组装一直是人们感兴趣的问题。胶原样多肽(CLP)又称胶原样多肽(CMP)或胶原相关多肽(CRP)，因此被广泛用于研究胶原蛋白的三螺旋结构，以及模拟天然胶原纤维的高阶结构。这篇简短的综述概述了这些主题在三个主要主题领域的最新进展。第一部分重点介绍了胶原蛋白三螺旋稳定的化学基础的研究进展，我们不是为了描述胶原蛋白的基本结构和生物学功能，而是为了总结设计具有高热稳定性的胶原蛋白样肽的不同途径。然后讨论了通过不同类型的分子间相互作用通过CLP自组装来产生高阶结构的各种方法。最后，总结了聚合物-CLP生物结合物生产这一新领域的最新进展。含有胶原蛋白的水凝胶的生物应用也包括在这一部分。这些课题可以作为设计胶原蛋白样多肽及其生物结合物的指南，用于生物医学领域的靶向应用。
Collagen is the most abundant protein in mammals, and there has been long-standing interest in understanding and controlling collagen assembly in the design of new materials. Collagen-like peptides (CLP), also known as collagen-mimetic peptides (CMP) or collagen-related peptides (CRP), have thus been widely used to elucidate collagen triple helix structure as well as to produce higher-order structures that mimic natural collagen fibers. This mini-review provides an overview of recent progress on these topics, in three broad topical areas. The first focuses on reported developments in deciphering the chemical basis for collagen triple helix stabilization, which we review not with the intent of describing the basic structure and biological function of collagen, but to summarize different pathways for designing collagen-like peptides with high thermostability. Various approaches for producing higher-order structures via CLP self-assembly, via various types of intermolecular interaction, are then discussed. Finally, recent developments in a new area, the production of polymer-CLP bioconjugates, are summarized. Biological applications of collagen contained hydrogels are also included in this section. The topics may serve as a guide for the design of collagen-like peptides and their bioconjugates for targeted application in the biomedical arena.
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影响因子：
15
作者：
DeRider, ML;Wilkens, SJ;Markley, JL
通讯作者：
Markley, JL
PLGA/胶原杂化支架结构设计对软骨组织工程的影响
影响因子：
14
作者：
Dai, Wenda;Kawazoe, Naoki;Chen, Guoping
通讯作者：
Chen, Guoping
影响因子：
15
作者：
Bretscher, LE;Jenkins, CL;Raines, RT
通讯作者：
Raines, RT
影响因子：
5.6
作者：
Frank, S;Kammerer, RA;Engel, J
通讯作者：
Engel, J
DOI：
10.1073/pnas.0800291105
发表时间：
2008-06-24
影响因子：
11.1
作者：
Cejas, Mabel A.;Kinnney, William A.;Maryanoff, Bruce E.
通讯作者：
Maryanoff, Bruce E.