The Burden of Critical Illness in Hospitalized Children in Low- and Middle-Income Countries: Protocol for a Systematic Review and Meta-Analysis.
The Burden of Critical Illness in Hospitalized Children in Low- and Middle-Income Countries: Protocol for a Systematic Review and Meta-Analysis.
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DOI：
10.3389/fped.2022.756643
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发表时间：
2022
影响因子：
2.6
通讯作者：
Bhutta AT
中科院分区：
文献类型：
--
作者：
Kortz TB;Nielsen KR;Mediratta RP;Reeves H;O'Brien NF;Lee JH;Attebery JE;Bhutta EG;Biewen C;Coronado Munoz A;deAlmeida ML;Fonseca Y;Hooli S;Johnson H;Kissoon N;Leimanis-Laurens ML;McCarthy AM;Pineda C;Remy KE;Sanders SC;Takwoingi Y;Wiens MO;Bhutta AT
大多数儿童死亡发生在低收入和中等收入国家。其中许多死亡是可以通过基本的重症护理干预措施避免的。量化中低收入国家儿科危重疾病的负担对于降低儿童死亡率的干预措施至关重要。通过对文献的系统回顾和荟萃分析，确定LMIC中与急性儿科危重病相关的住院负担和死亡率。我们将通过使用MeSH术语和关键词检索MEDLINE、EMBASE、CINAHL和LILACS来识别合格研究。结果将仅限于在LMIC住院的婴儿或儿童（年龄>28天至12岁）和英语、西班牙语或法语出版物。非原始数据的出版物（例如，评论，社论，信件，笔记，会议材料）将被排除在外。我们将纳入自2005年1月1日以来发表的观察性研究，这些研究符合所有资格标准，并且可以找到全文。数据提取将包括与研究特征、医院特征、基础人群特征、患者人群特征和结局相关的信息。我们将提取和报告有关研究、医院和患者特征、结局和偏倚风险的数据。我们将按地区、国家收入水平和年龄报告入院和死亡的原因。在数据允许的情况下，我们将报告或计算每个诊断的病死率（CFR）。通过了解中低收入国家儿科危重病的负担，我们可以倡导资源，并为资源分配和投资决策提供信息，以改善中低收入国家急性儿科危重病儿童的管理和结局。
The majority of childhood deaths occur in low- and middle-income countries (LMICs). Many of these deaths are avoidable with basic critical care interventions. Quantifying the burden of pediatric critical illness in LMICs is essential for targeting interventions to reduce childhood mortality. To determine the burden of hospitalization and mortality associated with acute pediatric critical illness in LMICs through a systematic review and meta-analysis of the literature. We will identify eligible studies by searching MEDLINE, EMBASE, CINAHL, and LILACS using MeSH terms and keywords. Results will be limited to infants or children (ages >28 days to 12 years) hospitalized in LMICs and publications in English, Spanish, or French. Publications with non-original data (e.g., comments, editorials, letters, notes, conference materials) will be excluded. We will include observational studies published since January 1, 2005, that meet all eligibility criteria and for which a full text can be located. Data extraction will include information related to study characteristics, hospital characteristics, underlying population characteristics, patient population characteristics, and outcomes. We will extract and report data on study, hospital, and patient characteristics; outcomes; and risk of bias. We will report the causes of admission and mortality by region, country income level, and age. We will report or calculate the case fatality rate (CFR) for each diagnosis when data allow. By understanding the burden of pediatric critical illness in LMICs, we can advocate for resources and inform resource allocation and investment decisions to improve the management and outcomes of children with acute pediatric critical illness in LMICs.
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影响因子：
168.9
作者：
Bhutta, Zulfiqar A.;Das, Jai K.;Black, Robert E.
通讯作者：
Black, Robert E.
影响因子：
3.7
作者：
Moher D;Shamseer L;Clarke M;Ghersi D;Liberati A;Petticrew M;Shekelle P;Stewart LA;PRISMA-P Group
通讯作者：
PRISMA-P Group
影响因子：
168.9
作者：
Liu, Li;Oza, Shefali;Hogan, Dan;Chu, Yue;Perin, Jamie;Zhu, Jun;Lawn, Joy E.;Cousens, Simon;Mathers, Colin;Black, Robert E.
通讯作者：
Black, Robert E.
影响因子：
39.2
作者：
Tricco, Andrea C.;Lillie, Erin;Straus, Sharon E.
通讯作者：
Straus, Sharon E.
影响因子：
15.8
作者：
Profit, Jochen;Lee, Diana;Salomon, Joshua A.
通讯作者：
Salomon, Joshua A.