Evaluation of cold-recombinant influenza A/Korea (CR-59) virus vaccine in infants
Evaluation of cold-recombinant influenza A/Korea (CR-59) virus vaccine in infants
复制标题
婴儿冷重组甲型流感/韩国（CR-59）病毒疫苗的评价
DOI：
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发表时间：
1989
影响因子：
9.4
通讯作者：
H. F. Maassab
中科院分区：
文献类型：
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作者：
E. L. Anderson;R. Belshe;'. B. Burk;J. Bartram;And;H. F. Maassab
24名5至13个月大的婴儿鼻内接种了感冒重组甲型流感/朝鲜（CR-59, H3N2）病毒活疫苗。19名婴儿作为对照。接种范围为每名婴儿10（3.2）至10(6.2)50%组织培养感染剂量（TCID50）。接种10（3.2）、10（4.2）、10（5.2）和10(6.2)TCID50疫苗的婴儿中，分别有0 / 6、1 / 4、7 / 10和4 / 4被鼻内疫苗感染。感染50%婴儿所需的病毒量计算为10(4.6)TCID50。接种后对照组和接种者均出现发热、呼吸道疾病和中耳炎。在一些婴儿中存在低滴度的母源抗体，并且不抑制疫苗病毒的复制。
Twenty-four infants 5 to 13 months of age were intranasally vaccinated with a live cold-recombinant influenza A/Korea (CR-59, H3N2) virus vaccine. Nineteen infants served as controls. The inocula ranged from 10(3.2) to 10(6.2) 50% tissue culture infective doses (TCID50) per infant. Zero of six, one of four, seven of ten, and four of four infants receiving 10(3.2), 10(4.2), 10(5.2), and 10(6.2) TCID50, respectively, were infected by the intranasal vaccine. The amount of virus required to infect 50% of infants was calculated to be 10(4.6) TCID50. The occurrence of fever, respiratory illness, and otitis media was common among both controls and vaccinees in the postinoculation period. Maternal antibody was present in low titers in some infants and did not inhibit replication of the vaccine virus.
血清阴性幼儿的冷适应重组甲型流感病毒疫苗。
DOI：
10.1093/infdis/146.1.71
发表时间：
1982
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Wright,PF;Okabe,N;McKeeJr,KT;Maassab,HF;Karzon,DT
通讯作者：
Karzon,DT