Gains in employment status following antidepressant medication or cognitive therapy for depression.
Gains in employment status following antidepressant medication or cognitive therapy for depression.
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DOI：
10.1192/bjp.bp.113.133694
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Hollon SD
中科院分区：
文献类型：
--
作者：
Fournier JC;DeRubeis RJ;Amsterdam J;Shelton RC;Hollon SD
抑郁症会对就业状况产生不利影响。利用先前报道的一项试验的数据，研究认知疗法或抗抑郁药物在改善治疗后的就业状况方面是否有相对优势。随机分配到认知治疗（n = 48）或SSRI帕罗西汀（n = 93），为期4个月；治疗应答者的随访时间长达24个月。研究了不同待遇对就业状况的不同影响。在28个月结束时，认知治疗导致全职就业率（88.9%）高于抗抑郁药物（70.8%），X21 = 5.78, p = 0.02, OR = 5.66, 95% CI:1.16,27.69。在短期内，治疗对就业状况的主要影响在急性治疗后并不显著（X21 = 1.74, p = 0.19, OR = 1.77, 95% CI:0.75,4.17），然而，我们观察到一个地点与治疗的相互作用（X21 = 6.87, p = 0.009），即认知治疗导致一个地点的全职就业率更高，而在另一个地点则没有。与药物治疗相比，认知疗法在就业方面可能会产生更大的改善，尤其是从长期来看。
Depression can adversely affect employment status. To examine whether there is a relative advantage of cognitive therapy or antidepressant medication in improving employment status following treatment, using data from a previously reported trial. Random assignment to cognitive therapy (n = 48) or the SSRI paroxetine (n = 93) for 4 months; treatment responders were followed for up to 24 months. Differential effects of treatment on employment status were examined. At the end of 28 months, cognitive therapy led to higher rates of full-time employment (88.9%) than did antidepressant medication (70.8%), X21 = 5.78, p = 0.02, OR = 5.66, 95% CI:1.16,27.69. In the shorter-term, the main effect of treatment on employment status was not significant following acute treatment (X21 = 1.74, p = 0.19, OR = 1.77, 95% CI:0.75,4.17), however, we observed a site-by-treatment interaction (X21 = 6.87, p = 0.009) whereby cognitive therapy led to a higher rate of full-time employment at one site but not at the other. Cognitive therapy may produce greater improvements in employment versus medication, particularly over the longer-term.
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影响因子：
6.9
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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