Pen microfluidics: rapid desktop manufacturing of sealed thermoplastic microchannels.

Pen microfluidics: rapid desktop manufacturing of sealed thermoplastic microchannels.
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DOI:
10.1039/c2lc41057e
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发表时间:
2013-03-21
期刊:
影响因子:
6.1
通讯作者:
DeVoe DL
DeVoe DL
中科院分区:
工程技术1区
文献类型:
--
作者:
Rahmanian O;DeVoe DL

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A unique technique for the rapid fabrication of thermoplastic microfluidic chips is described. The method enables the realization of fully-sealed microchannels in around one hour while requiring only minimal infrastructure by taking advantage of a solvent swelling mechanism that allows raised features to be patterned on the surface of homogeneous thermoplastic materials. Patterning is achieved without photolithography by simply drawing the desired microchannel pattern onto the polymer surface using a suitable ink as a masking layer, either manually or under robotic control, followed by timed exposure to solvent vapor to yield a desired depth for the masked channel features. The channels are then permanently sealed through solvent bonding of the microchannel chip to a mating thermoplastic substrate. The process is demonstrated using cyclic olefin copolymer as a thermoplastic material, with fully operational microfluidic devices fabricated following a true desktop manufacturing model suitable for rapid prototyping.
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