The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities.
The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities.
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DOI：
10.1080/14737140.2018.1417844
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发表时间：
2018-03
影响因子：
3.3
通讯作者：
Philip PA
中科院分区：
文献类型：
--
作者：
Tesfaye AA;Kamgar M;Azmi A;Philip PA
预计到 2030 年，胰腺导管腺癌 (PDAC) 将成为美国癌症相关死亡的第二大原因，尽管经过数十年的广泛研究，其 5 年总生存率仍低于 10%。胰腺癌的特点是复杂的分子变化的积累、复杂的肿瘤间质相互作用以及免疫抑制的肿瘤微环境。 PDAC 已被证明对许多细胞毒性、靶向和免疫治疗方法具有抵抗力。在本文中，我们回顾了 PDAC 的主要研究领域，重点介绍了个性化治疗方法的挑战和机遇领域。胰腺癌的研究重点已经不再是开发传统的细胞毒性组合。在理解这种疾病的分子生物学方面取得的显着进展，特别是在微环境、代谢和 DNA 修复领域，为开发新的治疗策略开辟了新的机会。提高对分子异常的了解有助于开发个性化治疗方法。
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer related mortality in the United States in 2030, with a 5-year overall survival of less than 10% despite decades of extensive research. Pancreatic cancer is marked by the accumulation of complex molecular changes, complex tumor-stroma interaction, and an immunosuppressive tumor microenvironment. PDAC has proven to be resistant to many cytotoxic, targeted and immunologic treatment approaches. In this paper, we review the major areas of research in PDAC, with highlights on the challenges and areas of opportunity for personalized treatment approaches. The focus of research in pancreatic cancer has moved away from developing conventional cytotoxic combinations. The marked advances in understanding the molecular biology of this disease especially in the areas of the microenvironment, metabolism, and DNA repair have opened new opportunities for developing novel treatment strategies. Improved understanding of molecular abnormalities allows the development of personalized treatment approaches.
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影响因子：
29.4
作者：
Apte MV;Wilson JS;Lugea A;Pandol SJ
通讯作者：
Pandol SJ
影响因子：
7.3
作者：
Amato, Eliana;dal Molin, Marco;Mafficini, Andrea;Yu, Jun;Malleo, Giuseppe;Rusev, Borislav;Fassan, Matteo;Antonello, Davide;Sadakari, Yoshihiko;Castelli, Paola;Zamboni, Giuseppe;Maitra, Anirban;Salvia, Roberto;Hruban, Ralph H.;Bassi, Claudio;Capelli, Paola;Lawlor, Rita T.;Goggins, Michael;Scarpa, Aldo
通讯作者：
Scarpa, Aldo
影响因子：
--
作者：
Assenat E;Azria D;Mollevi C;Guimbaud R;Tubiana-Mathieu N;Smith D;Delord JP;Samalin E;Portales F;Larbouret C;Robert B;Bibeau F;Bleuse JP;Crapez E;Ychou M;Pèlegrin A
通讯作者：
Pèlegrin A
影响因子：
5.2
作者：
Bharadwaj, Uddalak;Li, Min;Yao, Qizhi
通讯作者：
Yao, Qizhi
影响因子：
64.8
作者：
Bailey, Peter;Chang, David K.;Grimmond, Sean M.
通讯作者：
Grimmond, Sean M.