Towards dynamical network biomarkers in neuromodulation of episodic migraine.

Towards dynamical network biomarkers in neuromodulation of episodic migraine.
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DOI:
10.2478/s13380-013-0127-0
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发表时间:
2013-09
影响因子:
2.1
通讯作者:
Kurths J
Kurths J
中科院分区:
医学4区
文献类型:
--
作者:
Dahlem MA;Rode S;May A;Fujiwara N;Hirata Y;Aihara K;Kurths J

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计算方法补充了实验和临床神经科学,并提高了我们对健康和疾病神经系统的理解。与此同时,电刺激和磁刺激形式的神经调节在慢性和难治性疾病中越来越被接受。在本文中,我们首先探讨了转化计算神经科学两种发展融合的相关最新技术。然后,我们提出了一种策略,在慢性疾病的发作性表现中采用动态网络生物标志物(DNB)的新理论概念。特别是,作为第一个例子,我们介绍了计算模型在偏头痛中的使用,并在此示例的基础上说明了 DNB 作为阵发性偏头痛神经调节早期预警信号的潜力。
Computational methods have complemented experimental and clinical neurosciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic stimulation is gaining increasing acceptance in chronic and intractable diseases. In this paper, we firstly explore the relevant state of the art in fusion of both developments towards translational computational neuroscience. Then, we propose a strategy to employ the new theoretical concept of dynamical network biomarkers (DNB) in episodic manifestations of chronic disorders. In particular, as a first example, we introduce the use of computational models in migraine and illustrate on the basis of this example the potential of DNB as early-warning signals for neuromodulation in episodic migraine.
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