Imaging of dialysis-related amyloid (AB-amyloid) deposits with 131I-beta 2-microglobulin.
Imaging of dialysis-related amyloid (AB-amyloid) deposits with 131I-beta 2-microglobulin.
复制标题
使用 131I-β2-微球蛋白对透析相关淀粉样蛋白（AB-淀粉样蛋白）沉积物进行成像。
作者：
J. Floege;W. Burchert;A. Brandis;P. Gielow;B. Nonnast;E. Spindler;H. Hundeshagen;S. Shaldon;K. Koch
透析相关淀粉样蛋白（ab -淀粉样蛋白）的诊断通常基于临床和放射学标准。在发现β 2-微球蛋白是该淀粉样蛋白的主要蛋白后，我们分离并放射性标记了尿毒症血浆β 2-微球蛋白。在静脉注射后，对42例接受常规血液透析治疗的患者的选定关节区域进行伽玛相机成像。14例治疗10年以上的患者中有13例扫描结果呈阳性，16例治疗5至10年的患者中有10例扫描结果呈阳性。治疗时间较短的患者扫描结果为阴性。特异性通过阴性扫描在对照血液透析患者的非淀粉样炎性病变中显示。与不含淀粉样蛋白的组织相比，在切除的含有ab -淀粉样蛋白的组织中检测到高达48倍的示踪剂富集。这些发现表明，循环放射性标记的β 2微球蛋白被淀粉样蛋白沉积物所吸收。这种方法可以无创地检测淀粉样蛋白的组织浸润。它也允许前瞻性评估预防性透析策略的有效性，该策略旨在预防或延迟长期透析并发症的发生。
The diagnosis of dialysis-related amyloid (AB-amyloid) has been based usually on clinical and radiological criteria. Following the discovery that beta 2-microglobulin was the major protein of this amyloid, we isolated and radiolabelled uremic plasma beta 2-microglobulin. After intravenous injection, gamma-camera images of selected joint areas were obtained from 42 patients who were on regular hemodialysis therapy. Positive scans involving the shoulder, hip, knee and carpal regions were found in 13 of 14 patients treated for more than 10 years and 10 of 16 patients treated for 5 to 10 years. Patients treated for less time had negative scans. Specificity was indicated by negative scans in non-amyloid inflammatory lesions in control hemodialysis patients. Up to 48-fold tracer enrichment was detected in excised AB-amyloid containing tissue as compared to amyloid-free tissue. These findings suggest that circulating radiolabelled beta 2-microglobulin is taken up by the amyloid deposits. This method may non-invasively detect tissue infiltrates of amyloid. It may also permit prospective evaluation of the efficacy of prophylactic dialysis strategies which are designed to prevent or delay the onset of this complication of long-term dialysis.
长期血液透析患者的腹部脂肪抽吸物中缺乏淀粉样蛋白。
影响因子：
--
作者：
Varga,J;Idelson,BA;Felson,D;Skinner,M;Cohen,AS
通讯作者：
Cohen,AS
DOI：
10.1016/0006-291x(85)91948-5
发表时间：
1985-01-01
影响因子：
3.1
作者：
GEJYO, F;YAMADA, T;SCHMID, K
通讯作者：
SCHMID, K