The choice of the source space and the Laplacian matrix in LORETA and the spatio-temporal Kalman filter EEG inverse methods
The choice of the source space and the Laplacian matrix in LORETA and the spatio-temporal Kalman filter EEG inverse methods
复制标题
LORETA中源空间和拉普拉斯矩阵的选择及时空卡尔曼滤波脑电逆方法
DOI：
10.1109/embc.2015.7318960
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
M. Siniatchkin
中科院分区：
文献类型：
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作者：
N. Habboush;L. Hamid;N. Japaridze;G. Wiegand;U. Heute;U. Stephani;A. Galka;M. Siniatchkin
大脑的离散化和拉普拉斯矩阵的定义影响基于空间和时空平滑度的方法的结果，因为拉普拉斯算子用于基于每个网格点的邻域来定义平滑度。在本文中，低分辨率电磁层析成像（LORETA）和时空卡尔曼滤波器（STKF）的结果计算，第一，一个灰物质源空间与拉普拉斯矩阵的标准定义，第二，使用全脑源空间和拉普拉斯矩阵的修改后的定义。一位癫痫患者手术前的五个发作间期棘波的脑电图（EEG）源成像结果被用来验证上述两种方法。使用全脑源空间和拉普拉斯矩阵的修改定义的结果集中在一个单一的源激活，稳定，并与患者的大脑中的局灶性皮质发育不良（FCD）的位置相一致的结果相比，使用灰质网格和拉普拉斯矩阵的经典定义。这项概念验证研究证明了LORETA和STKF对源定位的实质性改善，并为在大量癫痫患者中进行进一步研究奠定了基础。
The discretization of the brain and the definition of the Laplacian matrix influence the results of methods based on spatial and spatio-temporal smoothness, since the Laplacian operator is used to define the smoothness based on the neighborhood of each grid point. In this paper, the results of low resolution electromagnetic tomography (LORETA) and the spatiotemporal Kalman filter (STKF) are computed using, first, a greymatter source space with the standard definition of the Laplacian matrix and, second, using a whole-brain source space and a modified definition of the Laplacian matrix. Electroencephalographic (EEG) source imaging results of five inter-ictal spikes from a pre-surgical patient with epilepsy are used to validate the two aforementioned approaches. The results using the whole-brain source space and the modified definition of the Laplacian matrix were concentrated in a single source activation, stable, and concordant with the location of the focal cortical dysplasia (FCD) in the patient's brain compared with the results which use a grey-matter grid and the classical definition of the Laplacian matrix. This proof-of-concept study demonstrates a substantial improvement of source localization with both LORETA and STKF and constitutes a basis for further research in a large population of patients with epilepsy.
DOI：
10.1016/j.clinph.2010.10.043
发表时间：
2011-06
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Wang G;Worrell G;Yang L;Wilke C;He B
通讯作者：
He B