Interictal spike analysis of high-density EEG in patients with partial epilepsy.

Interictal spike analysis of high-density EEG in patients with partial epilepsy.
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DOI:
10.1016/j.clinph.2010.10.043
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发表时间:
2011-06
期刊:
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子:
--
通讯作者:
He B
He B
中科院分区:
其他
文献类型:
--
作者:
Wang G;Worrell G;Yang L;Wilke C;He B

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本研究的目的是研究使用发作间期尖峰从难治性癫痫患者的无创头皮脑电图记录中定位致癫痫脑。通过分布式源建模方法,使用高密度电极蒙太奇和低密度电极蒙太奇进行源重建。使用现实几何边界元法 (BEM) 头部模型和 3 壳球形头部模型来定位发作间期尖峰活动的来源。在对 7 名患者的分析中,发现与常规临床实践中使用的空间低密度电极蒙太奇相比,高密度电极蒙太奇提供的结果与使用颅内 EEG 记录和结构 MRI 病变确定进行手术切除的疑似致癫痫脑区域更加一致。此外,真实的几何 BEM 头部模型提供了更好的源定位。我们的结果表明,使用高密度头皮脑电图记录和逼真的几何头部模型来定位部分癫痫患者的发作间期尖峰的源头具有优点。目前的结果表明,使用高密度头皮电极蒙太奇和逼真的几何头部模型记录的发作间期脑电图可以进一步提高致痫脑的源定位准确性。
The aim of this study is to investigate the use of interictal spikes to localize epileptogenic brain from noninvasive scalp EEG recordings in patients with medically intractable epilepsy. Source reconstructions were performed using a high density electrode montage and a low density electrode montage by means of a distributed source modeling method. The source of interictal spike activity was localized using both realistic geometry boundary element method (BEM) head models and the 3-shell spherical head model. In the analysis of 7 patients, the high density electrode montage was found to provide results more consistent with the suspected region of epileptogenic brain identified for surgical resection using intracranial EEG recordings and structural MRI lesions, as compared to the spatial low density electrode montage used in routine clinical practice. Furthermore, the realistic geometry BEM head model provided better source localization. Our results indicate the merits of using high density scalp EEG recordings and realistic geometry head modeling for source localization of interictal spikes in patients with partial epilepsy. The present results suggest further improvement of source localization accuracy of epileptogenic brain from interictal EEG recorded using high density scalp electrode montage and realistic geometry head models.
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