Normal patterns on 99mTc-ECD brain SPECT scans in adults.
Normal patterns on 99mTc-ECD brain SPECT scans in adults.
复制标题
成人 99mTc-ECD 脑部 SPECT 扫描的正常模式。
DOI：
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复制
发表时间：
2000
影响因子：
9.3
通讯作者：
Masanori Ichise
中科院分区：
文献类型：
--
作者：
Fumiko Tanaka;Douglass C. Vines;Tatsuro Tsuchida;Morris Freedman;Masanori Ichise
未标记
必须提供标准的乙基半胱氨酸二聚体（ECD）SPECT数据，以成功地将ECD SPECT应用于临床研究。本研究的目的是确定健康成人的ECD SPECT扫描模式。
方法
48名健康志愿者（22名男性，26名女性;年龄范围，22-95岁;平均年龄，47.6 ± 19.2岁）接受了高分辨率ECD SPECT。对于局部脑ECD摄取的视觉分析，我们使用+3至-3的量表，其中+3和-3分别表示最高的ECD摄取和缺陷。为了进行定量分析，我们测量了17个区域（13个皮质，3个皮质下和1个小脑）的区域-小脑比率（R/CE）和区域-大脑皮质比率（R/CO）。
结果
在视觉分析中，没有受试者的评分为-3。所有受试者的海马评分为-2，内侧枕叶皮质评分为+3，但2例受试者的纹状体和丘脑评分为+3。在60%的受试者（评分为+1）和79%的受试者（评分为+2）中确定了额叶眼野和后顶枕交界处。在定量分析中，R/CE存在显著的区域差异（ANOVA，P < 0.0001），范围从0.709（海马）到1.26（内侧枕叶皮质）。然而，R/CE的区域性左右差异和受试者间变异性较小（不对称指数，3.6% +/- 0.8%;变异系数，6.6% +/- 0.7%）。前扣带回、后扣带回、上级前额叶、顶叶、纹状体、海马等6个脑区的R/CE随年龄增长而显著下降（1.0%~ 2.0%/10年，P < 0.05），而小脑的R/CO随年龄增长而显著增加（1.0%/10年，P < 0.05）。
结论
尽管区域ECD脑灌注模式差异显著，包括年龄相关效应引起的变异性，但受试者间变异性较小。这些正常模式的识别是重要的ECD SPECT研究的临床解释。
UNLABELLED
Normative ethyl cysteinate dimer (ECD) SPECT data must be available to successfully apply ECD SPECT to clinical studies. The purpose of this study was to determine ECD SPECT scan patterns of healthy adults.
METHODS
Forty-eight healthy volunteers (22 men, 26 women; age range, 22-95 y; mean age, 47.6 +/- 19.2 y) underwent high-resolution ECD SPECT. For visual analysis of regional brain ECD uptake, we used a scale of +3 to -3, in which +3 and -3 indicated highest ECD uptake and deficit, respectively. For quantitative analysis, we measured the region-to-cerebellum ratio (R/CE) and the region-to-cerebral cortex ratio (R/CO) for 17 regions (13 cortical, 3 subcortical, and 1 cerebellar).
RESULTS
On visual analysis, no subject had a score of -3. All subjects had a score of -2 for the hippocampus and a score of +3 for the medial occipital cortex, except for 2 subjects who had a score of +3 for the striatum and thalamus. A frontal eye field and posterior parieto-occipital junction were identified in 60% of subjects with a score of +1 and 79% of subjects with a score of +2. On quantitative analysis, a significant regional variation (ANOVA, P < 0.0001) was seen in R/CE, ranging from 0.709 (hippocampus) to 1.26 (medial occipital cortex). However, regional right-to-left differences and intersubject variability of R/CE were small (asymmetry index, 3.6% +/- 0.8%; coefficient variation, 6.6% +/- 0.7%). R/CE declined significantly with age in 6 regions, including the anterior and posterior cingulate cortex, superior prefrontal and parietal cortex, striatum, and hippocampus (1.0%-2.0% per decade, P < 0.05), whereas R/CO in the cerebellum increased significantly with age (1.0% per decade, P < 0.05).
CONCLUSION
Although regional ECD brain perfusion patterns vary significantly, including variability caused by the age-related effect, intersubject variability is small. Recognition of these normal patterns is important for clinical interpretation of ECD SPECT studies.
DOI：
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发表时间：
1995-07
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
A. Loessner;A. Alavi;K. Lewandrowski;D. Mozley;E. Souder;R. Gur
通讯作者：
A. Loessner;A. Alavi;K. Lewandrowski;D. Mozley;E. Souder;R. Gur
通过重复 Technetium-99m-HMPAO SPECT 测量脑血流的区域稳定性：对状态依赖性变化研究的影响。
DOI：
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发表时间：
1997
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
影响因子：
--
作者：
Deutsch,G;Mountz,JM;Katholi,CR;Liu,HG;Harrell,LE
通讯作者：
Harrell,LE
technetium-99m-HMPAO 和 technetium-99m-ECD 大脑 SPECT 图像在阿尔茨海默病中的比较。
DOI：
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发表时间：
1996
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
vanDyck,CH;Lin,CH;Smith,EO;Wisniewski,G;Cellar,J;Robinson,R;Narayan,M;Bennett,A;Delaney,RC;Bronen,RA;Hoffer,PB
通讯作者：
Hoffer,PB