Effects of a Diet Higher in Carbohydrate/Lower in Fat Versus Lower in Carbohydrate/Higher in Monounsaturated Fat on Postmeal Triglyceride Concentrations and Other Cardiovascular Risk Factors in Type 1 Diabetes
Effects of a Diet Higher in Carbohydrate/Lower in Fat Versus Lower in Carbohydrate/Higher in Monounsaturated Fat on Postmeal Triglyceride Concentrations and Other Cardiovascular Risk Factors in Type 1 Diabetes
复制标题
高碳水化合物/低脂肪饮食与低碳水化合物/高单不饱和脂肪饮食对 1 型糖尿病餐后甘油三酯浓度和其他心血管危险因素的影响
作者：
I. Strychar;J. Cohn;G. Renier;M. Rivard;N. Aris;H. Beauregard;S. Meltzer;A. Bélanger;R. Dumas;Alain Ishac;F. Radwan;J. Yale
目的比较高碳水化合物/低脂肪与低碳水化合物/高单不饱和脂肪的正常热量饮食对血糖控制良好的非肥胖1型糖尿病受试者餐后甘油三酯（TG）浓度和其他心血管疾病危险因素的影响。研究设计和方法在一项平行组设计的研究中，30名受试者被随机分配并完成两种正常热量饮食中的一种。评估包括：BMI、血压、A1 C、血脂以及氧化、血栓形成和炎症标志物。在6个月时，受试者住院24小时以测量血浆TG波动。结果：除了低碳水化合物/高单不饱和脂肪组中纤溶酶原激活物抑制剂1（派-1）水平降低和体重增加外，两组之间无显著差异。在24小时测试期间，低碳水化合物/高单不饱和脂肪组的血浆TG水平较低。结论：低碳水化合物/高单不饱和脂肪的饮食可以为代谢和体重控制良好的非肥胖1型糖尿病患者提供适当的选择。
OBJECTIVE To compare the effects of a eucaloric diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride (TG) concentrations and other cardiovascular disease risk factors in nonobese subjects with type 1 diabetes and in good glycemic control. RESEARCH DESIGN AND METHODS In a parallel group design study, 30 subjects were randomly assigned and completed one of the two eucaloric diets. Assessments included: BMI, blood pressure, A1C, plasma lipids, and markers of oxidation, thrombosis, and inflammation. At 6 months, subjects were hospitalized for 24 h to measure plasma TG excursions. RESULTS There were no significant differences between groups other than decreased plasminogen activator inhibitor 1 (PAI-1) levels and weight gain in the lower-carbohydrate/higher–monounsaturated fat group. During the 24-h testing, the lower-carbohydrate/higher–monounsaturated fat group had a lower plasma TG profile. CONCLUSIONS A diet lower in carbohydrate/higher in monounsaturated fat could offer an appropriate choice for nonobese type 1 diabetic individuals with good metabolic and weight control.
影响因子：
7.1
作者：
Garg, A
通讯作者：
Garg, A