Does age moderate the relationship between depressive symptoms and suicidal ideation in middle-aged and older patients with schizophrenia and subthreshold depression?
Does age moderate the relationship between depressive symptoms and suicidal ideation in middle-aged and older patients with schizophrenia and subthreshold depression?
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DOI：
10.1016/j.jagp.2013.01.039
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发表时间：
2014-05
影响因子：
7.2
通讯作者：
Zisook, Sidney
中科院分区：
文献类型：
--
作者：
Kasckow, John;Golshan, Shahrokh;Zisook, Sidney
中老年精神分裂症患者的自杀死亡是一个公共卫生问题。抑郁症和精神分裂症是自杀的主要危险因素。然而，尚不清楚年龄是否缓和了精神分裂症和阈值下抑郁症患者的抑郁和自杀意念之间的关系。采用Intersept自杀意念评定量表和CGI-自杀严重度量表对213例39岁精神分裂症和阈值下抑郁症患者的自杀意念进行评估。通过线性回归，我们检验了抑郁(基于卡尔加里抑郁评定量表评分)、年龄和抑郁症状导致的年龄是否可以预测自杀意念。抑郁症状预示着有自杀念头。年龄和“按年龄划分的抑郁症状”都不能预测自杀念头。在这一人群中，年龄似乎并不能缓和抑郁症状和自杀行为之间的关系。因此，评估抑郁症状作为危险因素在这一人群中的各个年龄段都很重要。
Suicidal deaths in middle aged and older individuals with schizophrenia is a public health concern. Depression and schizophrenia are major risk factors for suicide. However, it is unknown whether age moderates the relationship between depression and suicidal ideation in patients with schizophrenia and subthreshold depression. In outpatients > 39 years old with schizophrenia and subthreshold depression (n = 213), suicidal ideation was assessed with the Intersept Scale for Suicidal Ideation and CGI- Suicide Severity scale. Using linear regression, we examined whether depression (based on Calgary Depression Rating Scale scores), age and ‘age by depressive symptoms’ predicted suicidal ideation. Depressive symptoms predicted suicidal ideation. Neither age nor ‘depressive symptoms by age’ predicted suicidal ideation. In this population, age does not appear to moderate the relationship between depressive symptoms and suicidal behavior. Thus, assessing depressive symptoms as a risk factor is important at all ages in this population.
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影响因子：
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