Gait speed in clinical and daily living assessments in Parkinson's disease patients: performance versus capacity.
Gait speed in clinical and daily living assessments in Parkinson's disease patients: performance versus capacity.
复制标题
DOI：
10.1038/s41531-021-00171-0
复制
发表时间：
2021-03-05
期刊：
影响因子：
--
通讯作者：
Aminian K
中科院分区：
文献类型：
--
作者：
Atrsaei A;Corrà MF;Dadashi F;Vila-Chã N;Maia L;Mariani B;Maetzler W;Aminian K
步态速度通常被称为第六生命体征，是最有力的移动性生物标志物。虽然临床设置允许在呈现功能容量的受控条件下估计步态速度，但真实条件下的步态速度提供患者的实际表现。这项研究的目的是客观地调查在什么条件下，患者在日常活动中的表现与临床一样好或更好。为此，我们招募了27名帕金森病(PD)患者，并通过临床上的多次步行测试和他们在家中的日常活动，使用惯性测量装置测量了他们的步速。通过将双峰高斯模型与他们的步速分布进行拟合，我们发现，平均而言，患者在临床和日常活动中有相似的模式。此外，我们观察到，全天服用的药物剂量与诊所和家庭之间的差异有适度的相关性。在家庭评估期间对步态速度进行逐个周期的分析，总体而言，只有大约3%的步幅等于或超过临床患者的能力。这些步态发生在长距离步行运动中(>；1 )，发生在正午前，服药后约26 min，在服用左旋多巴后3 h达到最大概率。这些结果为更好地控制帕金森病患者的药物摄入量提供了可能，可以同时考虑功能容量和在实际条件下对步态速度的持续监测。
Gait speed often referred as the sixth vital sign is the most powerful biomarker of mobility. While a clinical setting allows the estimation of gait speed under controlled conditions that present functional capacity, gait speed in real-life conditions provides the actual performance of the patient. The goal of this study was to investigate objectively under what conditions during daily activities, patients perform as well as or better than in the clinic. To this end, we recruited 27 Parkinson’s disease (PD) patients and measured their gait speed by inertial measurement units through several walking tests in the clinic as well as their daily activities at home. By fitting a bimodal Gaussian model to their gait speed distribution, we found that on average, patients had similar modes in the clinic and during daily activities. Furthermore, we observed that the number of medication doses taken throughout the day had a moderate correlation with the difference between clinic and home. Performing a cycle-by-cycle analysis on gait speed during the home assessment, overall only about 3% of the strides had equal or greater gait speeds than the patients’ capacity in the clinic. These strides were during long walking bouts (>1 min) and happened before noon, around 26 min after medication intake, reaching their maximum occurrence probability 3 h after Levodopa intake. These results open the possibility of better control of medication intake in PD by considering both functional capacity and continuous monitoring of gait speed during real-life conditions.
登录
查看更多内容
影响因子：
2.4
作者：
Bock, Otmar;Beurskens, Rainer
通讯作者：
Beurskens, Rainer
影响因子：
2.8
作者：
Feltz, DL;Payment, CA
通讯作者：
Payment, CA
影响因子：
2.2
作者：
Godfrey A;Del Din S;Barry G;Mathers JC;Rochester L
通讯作者：
Rochester L
影响因子：
2.4
作者：
Aminian, K;Najafi, B;Robert, P
通讯作者：
Robert, P
影响因子：
4.6
作者：
Carcreff, Lena;Gerber, Corinna N.;Armand, Stephane
通讯作者：
Armand, Stephane