The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients.
The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients.
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DOI：
10.1038/bjc.2014.163
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发表时间：
2014-05-13
影响因子：
8.8
通讯作者：
Langsenlehner, T.
中科院分区：
文献类型：
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作者：
Krenn-Pilko, S.;Langsenlehner, U.;Thurner, E-M;Stojakovic, T.;Pichler, M.;Gerger, A.;Kapp, K. S.;Langsenlehner, T.
血小板与淋巴细胞比率（PLR）是一种基于血小板和淋巴细胞计数的易于应用的血液检测，其升高与不同类型癌症患者的不良预后有关。本研究旨在探讨术前PLR在一大批乳腺癌患者中的预后意义。对1999年至2004年间接受治疗的793例连续非转移性乳腺癌患者的数据进行回顾性评估。利用接收机工作曲线分析计算出PLR的最佳截止值。采用Kaplan-Meier法评估肿瘤特异性生存期（CSS）、总生存期（OS）和远端无转移生存期（DMFS）。为了评估PLR的独立预后意义，对所有三个不同终点应用多变量Cox回归模型。单变量分析显示术前PLR升高与CSS之间存在显著相关性（风险比（HR）： 2.75, 95%可信区间（CI）： 1.57 ~ 4.83， P<0.001），多变量分析中仍具有统计学意义（HR: 2.03, 95% CI: 1.03 ~ 4.02， P=0.042）。在单变量分析（HR: 2.45, 95% CI: 1.43-4.20， P=0.001）和多变量分析（HR: 1.92, 95% CI: 1.01-3.67， P=0.047）中，PLR的增加也与OS的降低显著相关。此外，单变量分析显示，PLR增加对DMFS有显著影响（HR: 2.02, 95% CI: 1.18-3.44， P=0.010）。亚组分析显示，在所有乳腺癌亚型中，PLR升高与主要终点CSS存在显著关联。这种关联在腔内B肿瘤患者的多变量分析中仍具有重要意义（HR: 2.538, 95% CI: 1.043-6.177， P=0.040）。在这项研究中，我们确定了术前PLR作为乳腺癌患者生存的独立预后指标。需要对我们的发现进行独立验证。
The elevation of the platelet-to-lymphocyte ratio (PLR), an easily applicable blood test based on platelet and lymphocyte counts has been associated with poor prognosis in patients with different types of cancer. The present study was aimed to investigate the prognostic significance of the preoperative PLR in a large cohort of breast cancer patients. Data from 793 consecutive non-metastatic breast cancer patients, treated between 1999 and 2004, were evaluated retrospectively. The optimal cutoff values for the PLR were calculated using receiver operating curve analysis. Cancer-specific survival (CSS), overall survival (OS) as well as distant metastasis-free survival (DMFS) were assessed using the Kaplan–Meier method. To evaluate the independent prognostic significance of PLR, multivariable Cox regression models were applied for all three different end points. Univariable analysis revealed a significant association between the elevated preoperative PLR and CSS (hazard ratio (HR): 2.75, 95% confidence interval (CI): 1.57–4.83, P<0.001) that remained statistically significant in multivariable analysis (HR: 2.03, 95% CI: 1.03–4.02, P=0.042). An increased PLR was also significantly associated with decreased OS in univariable (HR: 2.45, 95% CI: 1.43–4.20, P=0.001) and in multivariable analysis (HR: 1.92, 95% CI: 1.01–3.67, P=0.047). Furthermore, univariable analysis showed a significant impact of increased PLR on DMFS (HR: 2.02, 95% CI: 1.18–3.44, P=0.010). Subgroup analysis revealed significant associations of the elevated PLR on the primary end point CSS for all breast cancer subtypes. This association retained its significance in multivariable analysis in patients with luminal B tumours (HR: 2.538, 95% CI: 1.043–6.177, P=0.040). In this study, we identified the preoperative PLR as an independent prognostic marker for survival in breast cancer patients. Independent validation of our findings is needed.
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作为转移性结直肠癌的不良预后和预测因素，初始中性粒细胞淋巴细胞比率优于血小板淋巴细胞比率
影响因子：
3.4
作者：
He, Wenzhuo;Yin, Chenxi;Xia, Liangping
通讯作者：
Xia, Liangping
影响因子：
45.3
作者：
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通讯作者：
Green, Andrew R.
影响因子：
8.8
作者：
通讯作者：
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影响因子：
3.1
作者：
Benoy, Ina;Salgado, Roberto;Dirix, Luc Y
通讯作者：
Dirix, Luc Y
影响因子：
20.4
作者：
Koch, Andrea;Fohlin, Helena;Sorenson, Sverre
通讯作者：
Sorenson, Sverre