Experience-dependent structural plasticity in the cortex.
Experience-dependent structural plasticity in the cortex.
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DOI：
10.1016/j.tins.2011.02.001
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发表时间：
2011-04
影响因子：
15.9
通讯作者：
Zuo, Yi
中科院分区：
文献类型：
--
作者：
Fu, Min;Zuo, Yi
突触是神经元回路的基本单位。突触可塑性可以通过突触强度的变化以及通过添加/移除突触来发生。双光子显微镜与荧光标记相结合，提供了一个强大的工具，可以窥视活体大脑并跟踪单个突触的结构重组。延时成像描绘了一幅动态的画面，其中突触结构的经验依赖性可塑性在不同的皮质区域和层之间以及神经元亚型之间变化。最近的研究表明，突触结构的形成和消除发生在各种感觉运动学习经验的皮层神经元的亚群迅速，稳定的突触结构与任务的持久记忆。因此，电路可塑性，介导的结构重塑，提供了一个潜在的机制，学习和记忆。
Synapses are the fundamental units of neuronal circuits. Synaptic plasticity can occur through changes in synaptic strength, as well as through the addition/removal of synapses. Two-photon microscopy, in combination with fluorescence labeling, offers a powerful tool to peek into the living brain and follow structural reorganization at individual synapses. Time-lapse imaging depicts a dynamic picture, in which experience-dependent plasticity of synaptic structures varies between different cortical regions and layers, as well as between neuronal subtypes. Recent studies have demonstrated that the formation and elimination of synaptic structures happens rapidly in a subpopulation of cortical neurons during various sensorimotor learning experiences, and that stabilized synaptic structures are associated with long-lasting memories for the task. Thus, circuit plasticity, mediated by structural remodeling, provides an underlying mechanism for learning and memory.
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影响因子：
25
作者：
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作者：
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