Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with (18)F-DPA-714 PET/CT.
Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with (18)F-DPA-714 PET/CT.
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DOI：
10.1007/s00259-018-4038-8
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发表时间：
2018-10
影响因子：
9.1
通讯作者：
Stroes ESG
中科院分区：
文献类型：
--
作者：
Verweij SL;Stiekema LCA;Delewi R;Zheng KH;Bernelot Moens SJ;Kroon J;Stroes CI;Versloot M;Piek JJ;Verberne HJ;Stroes ESG
急性冠状动脉综合征（ACS）的特征在于多水平炎症反应，包括骨髓和脾脏的活化，伴随着白细胞向循环中的增加释放。ACS后这种反应的持续时间尚不清楚。在这里，我们评估了急性冠状动脉综合征对急性和3个月后患者多水平炎症反应的影响。我们对8名患者和8名匹配的健康对照者进行了急性和ACS后3个月的18F-DPA-714 PET/CT。DPA-714是一种结合TSPO受体并在骨髓细胞中高度表达的PET示踪剂，用于评估造血活性。我们还通过流式细胞术对20例急性ACS患者和ACS后3个月的患者以及19例健康对照者的循环单核细胞和造血干细胞及祖细胞（HSPCs）进行了表征。在急性期，与健康对照组相比，患者骨髓（p = 0.012）和脾脏（p = 0.039）中的18F-DPA-714摄取分别高出1.4倍和1.3倍。这与循环HSPC数量高2.4倍相一致（p = 0.001）。ACS后3个月，骨髓中的18F-DPA-714摄取显著降低（p = 0.002），但脾脏中的18F-DPA-714摄取（p = 0.67）和循环HSPC数量（p = 0.75）均未观察到降低。18F-DPA-714 PET/CT显示ACS触发的造血器官激活是3个月以上长期细胞炎症反应的起始物，其特征在于循环白细胞及其前体的数量较高。这种多水平炎症反应可能为旨在降低ACS后高复发率的新治疗选择提供有吸引力的靶点。本文的在线版本（10.1007/s 00259 -018-4038-8）包含补充材料，可供授权用户使用。
An acute coronary syndrome (ACS) is characterized by a multi-level inflammatory response, comprising activation of bone marrow and spleen accompanied by augmented release of leukocytes into the circulation. The duration of this response after an ACS remains unclear. Here, we assessed the effect of an ACS on the multi-level inflammatory response in patients both acutely and after 3 months. We performed 18F-DPA-714 PET/CT acutely and 3 months post-ACS in eight patients and eight matched healthy controls. DPA-714, a PET tracer binding the TSPO receptor and highly expressed in myeloid cells, was used to assess hematopoietic activity. We also characterized circulating monocytes and hematopoietic stem and progenitor cells (HSPCs) by flow cytometry in 20 patients acutely and 3 months post-ACS and in 19 healthy controls. In the acute phase, patients displayed a 1.4-fold and 1.3-fold higher 18F-DPA-714 uptake in, respectively, bone marrow (p = 0.012) and spleen (p = 0.039) compared with healthy controls. This coincided with a 2.4-fold higher number of circulating HSPCs (p = 0.001). Three months post-ACS, 18F-DPA-714 uptake in bone marrow decreased significantly (p = 0.002), but no decrease was observed for 18F-DPA-714 uptake in the spleen (p = 0.67) nor for the number of circulating HSPCs (p = 0.75). 18F-DPA-714 PET/CT reveals an ACS- triggered hematopoietic organ activation as initiator of a prolonged cellular inflammatory response beyond 3 months, characterized by a higher number of circulating leukocytes and their precursors. This multi-level inflammatory response may provide an attractive target for novel treatment options aimed at reducing the high recurrence rate post-ACS. The online version of this article (10.1007/s00259-018-4038-8) contains supplementary material, which is available to authorized users.
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DOI：
10.1177/0271678x17710182
发表时间：
2017-08
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Owen DR;Narayan N;Wells L;Healy L;Smyth E;Rabiner EA;Galloway D;Williams JB;Lehr J;Mandhair H;Peferoen LA;Taylor PC;Amor S;Antel JP;Matthews PM;Moore CS
通讯作者：
Moore CS
DOI：
10.1089/scd.1.1996.5.213
发表时间：
1996-06-01
期刊：
Journal of hematotherapy
影响因子：
--
作者：
Sutherland, D R;Anderson, L;Chin-Yee, I
通讯作者：
Chin-Yee, I
影响因子：
39.3
作者：
Gaemperli, Oliver;Shalhoub, Joseph;Camici, Paolo G.
通讯作者：
Camici, Paolo G.
DOI：
10.1161/circimaging.113.001093
发表时间：
2014-05-01
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Kim, Eung Ju;Kim, Sungeun;Seo, Hong Seog
通讯作者：
Seo, Hong Seog
影响因子：
14.5
作者：
Hamelin, Lorraine;Lagarde, Julien;Sarazin, Marie
通讯作者：
Sarazin, Marie