Changes in urinary angiotensinogen posttreatment in pediatric IgA nephropathy patients.
Changes in urinary angiotensinogen posttreatment in pediatric IgA nephropathy patients.
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DOI：
10.1007/s00467-014-3028-8
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发表时间：
2015-06
影响因子：
3
通讯作者：
Kagami, Shoji
中科院分区：
文献类型：
--
作者：
Urushihara, Maki;Nagai, Takashi;Kinoshita, Yukiko;Nishiyama, Sato;Suga, Kenichi;Ozaki, Natsuko;Jamba, Ariunbold;Kondo, Shuji;Kobori, Hiroyuki;Kagami, Shoji
最近，我们发现慢性肾小球肾炎患儿尿血管紧张素原（AGT）水平升高，反映了肾内肾素-血管紧张素系统（RAS）的状态。因此，本研究旨在检验以下假设：尿AGT（UAGT）水平可作为儿童伊加肾病（IgAN）患者肾内RAS状态与RAS阻断治疗相关的特异性指标。我们测量了24例接受RAS阻断治疗2年的儿童IgAN患者的血浆和UAGT水平以及尿转化生长因子β（TGF-β）水平，之后我们对AGT、血管紧张素II（Ang II）和TGF-β进行了免疫组织化学分析。使用配对检验分析从基线到研究结束的变化。虽然血浆AGT水平没有变化，但RAS阻断后UAGT和TGF-β水平显著降低，伴随着AGT、Ang II和TGF-β的表达水平以及肾小球损伤的程度。基线UAGT水平与舒张压、尿蛋白水平、系膜细胞增生评分、肾组织AGT、Ang II和TGF-β表达水平呈正相关。这些数据表明，UAGT是一个有用的生物标志物肾内RAS激活，这是与肾小球损伤在RAS阻断儿童IgA肾病患者。
Recently, we demonstrated that urinary angiotensinogen (AGT) levels are increased and reflect intrarenal renin–angiotensin system (RAS) status in pediatric patients with chronic glomerulonephritis. Therefore, this study was performed to test the hypothesis that urinary AGT (UAGT) levels provide a specific index of intrarenal RAS status associated with RAS blockade treatment in pediatric IgA nephropathy (IgAN) patients. We measured plasma and UAGT levels and urinary transforming growth factor beta (TGF-β) levels, after which we performed immunohistochemical analysis of AGT, angiotensin II (Ang II), and TGF-β in 24 pediatric IgAN patients treated with RAS blockades for 2 years. Paired tests were used to analyze the changes from baseline to study end. Although there was no change in plasma AGT levels, UAGT and TGF-β levels were significantly decreased after RAS blockade, which was accompanied by the expression levels of AGT, Ang II, and TGF-β, as well as the magnitude of glomerular injury. Baseline UAGT levels positively correlated with diastolic blood pressure, urinary protein levels, scores for mesangial hypercellularity, and the expression levels of AGT, Ang II, and TGF-β in renal tissues. These data indicate that UAGT is a useful biomarker of intrarenal RAS activation, which is associated with glomerular injury during RAS blockade in pediatric IgAN patients.
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DOI：
10.1161/hypertensionaha.108.123802
发表时间：
2009-02
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Kobori H;Alper AB Jr;Shenava R;Katsurada A;Saito T;Ohashi N;Urushihara M;Miyata K;Satou R;Hamm LL;Navar LG
通讯作者：
Navar LG
影响因子：
15.9
作者：
LAFAYETTE, RA;MAYER, G;MEYER, TW
通讯作者：
MEYER, TW
影响因子：
15.9
作者：
DellItalia, LJ;Meng, QC;Oparil, S
通讯作者：
Oparil, S
DOI：
10.1016/j.jash.2008.04.008
发表时间：
2008-09-01
影响因子：
--
作者：
Kobori, Hiroyuki;Ohashi, Naro;Yamamoto, Tatsuo
通讯作者：
Yamamoto, Tatsuo
影响因子：
15.9
作者：
KAGAMI, S;BORDER, WA;NOBLE, NA
通讯作者：
NOBLE, NA