Remembering nutrient quality of sugar in Drosophila.

Remembering nutrient quality of sugar in Drosophila.
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DOI:
10.1016/j.cub.2011.03.032
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发表时间:
2011-05-10
期刊:
影响因子:
9.2
通讯作者:
Waddell, Scott
Waddell, Scott
中科院分区:
生物学1区
文献类型:
--
作者:
Burke, Christopher J.;Waddell, Scott

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味觉是大多数动物选择食物和饮料的早期阶段。检测甜味表明糖的存在和可能的热量含量。然而,甜味可能是一个不可靠的营养价值预测,因为一些糖不能代谢。此外,在哺乳动物和昆虫的味觉系统中,离散的糖是由相同的感觉神经元检测到的,这使得动物很难仅凭味觉就轻易区分不同糖的身份。在这里,我们使用果蝇的食欲记忆实验来研究糖的适口性和相对营养价值对记忆形成的贡献。我们发现适口性和营养价值都有助于增强食欲记忆。非营养糖形成的记忆较弱,可以通过补充无味但有营养的物质来增强。在训练的几分钟内,营养信息就会传递到大脑,然后它就可以用来指导对糖的偏好记忆的表达。因此,果蝇可以通过进食后的奖励评估系统快速学会区分糖,它们优先记住有营养的糖。
Taste is an early stage in food and drink selection for most animals. Detecting sweetness indicates the presence of sugar and possible caloric content. However, sweet taste can be an unreliable predictor of nutrient value because some sugars cannot be metabolized. In addition, discrete sugars are detected by the same sensory neurons in the mammalian and insect gustatory systems, making it difficult for animals to readily distinguish the identity of different sugars using taste alone. Here we used an appetitive memory assay in Drosophila to investigate the contribution of palatability and relative nutritional value of sugars to memory formation. We show that palatability and nutrient value both contribute to reinforcement of appetitive memory. Non-nutritious sugars formed less robust memory that could be augmented by supplementing with a tasteless but nutritious substance. Nutrient information is conveyed to the brain within minutes of training when it can be used to guide expression of a sugar-preference memory. Therefore flies can rapidly learn to discriminate between sugars using a post-ingestive reward evaluation system and they preferentially remember nutritious sugars.
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发表时间: 2007-01-01
期刊: Journal of visualized experiments : JoVE
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