CellLineNavigator: a workbench for cancer cell line analysis.
CellLineNavigator: a workbench for cancer cell line analysis.
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CellLineNavigator：癌细胞系分析的工作台。
DOI：
10.1093/nar/gks1012
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发表时间：
2013-01
影响因子：
14.9
通讯作者：
Teufel A
中科院分区：
文献类型：
--
作者：
Krupp M;Itzel T;Maass T;Hildebrandt A;Galle PR;Teufel A
CellLineNavigator 数据库可在 http://www.medicalgenomics.org/celllinenavigator 上免费获取，它是一个基于网络的工作台，用于对大量不同细胞系进行大规模比较。它旨在支持基因组学、系统生物学和转化生物医学研究领域的实验设计。目前，该纲要包含 317 种不同癌细胞系的全基因组表达谱，分为 57 种不同的病理状态和 28 种个体组织。为了扩大CellLineNavigator的范围，该数据库还与常用的生物信息学数据库和知识库紧密相连。为了确保轻松的数据访问和搜索能力，实现了简单的数据和直观的查询界面。它允许用户探索和过滤基因表达，重点关注病理或生理条件。对于更复杂的搜索，可以使用高级查询界面来查询（i）差异表达基因； (ii) 病理或生理状况； (iii) 基因名称或功能属性，例如京都基因百科全书和基因组通路图。这些查询也可以组合起来。最后，CellLineNavigator 允许通过直接链接到注释、可视化和集成发现 (DAVID) 生物信息学资源数据库，对差异调节基因进行额外的高级分析。
The CellLineNavigator database, freely available at http://www.medicalgenomics.org/celllinenavigator, is a web-based workbench for large scale comparisons of a large collection of diverse cell lines. It aims to support experimental design in the fields of genomics, systems biology and translational biomedical research. Currently, this compendium holds genome wide expression profiles of 317 different cancer cell lines, categorized into 57 different pathological states and 28 individual tissues. To enlarge the scope of CellLineNavigator, the database was furthermore closely linked to commonly used bioinformatics databases and knowledge repositories. To ensure easy data access and search ability, a simple data and an intuitive querying interface were implemented. It allows the user to explore and filter gene expression, focusing on pathological or physiological conditions. For a more complex search, the advanced query interface may be used to query for (i) differentially expressed genes; (ii) pathological or physiological conditions; or (iii) gene names or functional attributes, such as Kyoto Encyclopaedia of Genes and Genomes pathway maps. These queries may also be combined. Finally, CellLineNavigator allows additional advanced analysis of differentially regulated genes by a direct link to the Database for Annotation, Visualization and Integrated Discovery (DAVID) Bioinformatics Resources.
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影响因子：
50.3
作者：
Singh A;Greninger P;Rhodes D;Koopman L;Violette S;Bardeesy N;Settleman J
通讯作者：
Settleman J
影响因子：
14.9
作者：
Kanehisa M;Goto S;Sato Y;Furumichi M;Tanabe M
通讯作者：
Tanabe M
基因本体论：2011年的增强。
影响因子：
14.9
作者：
Gene Ontology Consortium
通讯作者：
Gene Ontology Consortium
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
14.9
作者：
Keshava Prasad TS;Goel R;Kandasamy K;Keerthikumar S;Kumar S;Mathivanan S;Telikicherla D;Raju R;Shafreen B;Venugopal A;Balakrishnan L;Marimuthu A;Banerjee S;Somanathan DS;Sebastian A;Rani S;Ray S;Harrys Kishore CJ;Kanth S;Ahmed M;Kashyap MK;Mohmood R;Ramachandra YL;Krishna V;Rahiman BA;Mohan S;Ranganathan P;Ramabadran S;Chaerkady R;Pandey A
通讯作者：
Pandey A