Modulation of immune homeostasis by commensal bacteria.
Modulation of immune homeostasis by commensal bacteria.
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DOI：
10.1016/j.mib.2010.12.003
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发表时间：
2011-02
影响因子：
5.4
通讯作者：
Littman DR
中科院分区：
文献类型：
--
作者：
Ivanov II;Littman DR
肠道细菌形成与哺乳动物宿主共同进化的常驻群落。除了在消化和收集能量方面发挥重要作用外，肠道细菌对粘膜免疫防御的正常运作至关重要。这些功能中的大多数归因于存在大量“无害”的常驻细菌，这些细菌稀释或占据肠道病原体的小生境，或诱导先天免疫应答，将细菌隔离在管腔中，从而淬灭粘膜免疫系统的过度激活。然而，最近变得明显的是，肠道细菌不仅仅是有益的旁观者，而是肠道免疫稳态的重要调节剂，并且微生物群的组成是预先确定粘膜免疫应答的类型和稳健性的主要因素。在这里，我们回顾了修改先天性和适应性免疫反应的微生物群个体成员的具体例子，我们专注于产生这种物种特异性信号并将其传递给宿主免疫系统的潜在机制。
Intestinal bacteria form a resident community that has co-evolved with the mammalian host. In addition to playing important roles in digestion and harvesting energy, commensal bacteria are crucial for the proper functioning of mucosal immune defenses. Most of these functions have been attributed to the presence of large numbers of “innocuous” resident bacteria that dilute or occupy niches for intestinal pathogens or induce innate immune responses that sequester bacteria in the lumen, thus quenching excessive activation of the mucosal immune system. However it has recently become obvious that commensal bacteria are not simply beneficial bystanders, but are important modulators of intestinal immune homeostasis and that the composition of the microbiota is a major factor in pre-determining the type and robustness of mucosal immune responses. Here we review specific examples of individual members of the microbiota that modify innate and adaptive immune responses, and we focus on potential mechanisms by which such species-specific signals are generated and transmitted to the host immune system.
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影响因子：
6.7
作者：
Bergstrom KS;Kissoon-Singh V;Gibson DL;Ma C;Montero M;Sham HP;Ryz N;Huang T;Velcich A;Finlay BB;Chadee K;Vallance BA
通讯作者：
Vallance BA
影响因子：
8.7
作者：
Grainger JR;Hall JA;Bouladoux N;Oldenhove G;Belkaid Y
通讯作者：
Belkaid Y
DOI：
10.1038/nrgastro.2010.117
发表时间：
2010-09
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Gareau MG;Sherman PM;Walker WA
通讯作者：
Walker WA
DOI：
10.1152/ajpgi.90227.2008
发表时间：
2008-11-01
影响因子：
4.5
作者：
Ewaschuk, Julia B.;Diaz, Hugo;Madsen, Karen L.
通讯作者：
Madsen, Karen L.
影响因子：
64.5
作者：
Garrett, Wendy S.;Lord, Graham M.;Glimcher, Laurie H.
通讯作者：
Glimcher, Laurie H.