Guamanian neurodegenerative disease
Guamanian neurodegenerative disease
复制标题
关岛神经退行性疾病
作者：
J. Ahlskog;S. Waring;L. Kurland;R. Petersen;T. Moyer;W. Harmsen;D. Maraganore;P. O'brien;C. Esteban;V. Bush
目的在西太平洋的关岛，神经退行性疾病(帕金森病、痴呆症和运动神经元病)的发病率很高。我们寻找证据支持这一假设，即这些情况是由钙和镁的营养不足引发的，导致继发性甲状腺功能亢进，继而促进钙和有毒重金属进入大脑。方法对12例圭亚那神经退行性疾病患者和12例查莫罗对照组的钙代谢指标及血清、尿液、指甲和头发中重金属含量进行分析。结果12例神经退行性疾病患者血清总钙、离子钙、25-羟基维生素D、24小时尿钙均正常。12例患者中有11例血清甲状旁腺激素水平和碱性磷酸酶水平正常。虽然少数患者和对照组的尿镁浓度较低，但没有患者的血磷或血镁值降低。患者组和对照组的血清和24小时尿重金属(铝、砷、镉、铜、铁、铅、锰、汞和锌)的中位数在统计学上是相似的，只是患者组的血铅略有升高，但尿铅没有上升。两组头发和指甲中的重金属浓度相似。结论没有证据支持钙代谢异常或重金属吸收异常是关岛神经退行性疾病发生的主要原因。
objective There is a high prevalence of neurodegenerative disease (parkinsonism, dementia, and motor neuron disease) on the western Pacific island of Guam. We sought evidence in support of the hypothesis that these conditions are triggered by nutritional deficiencies of calcium and magnesium leading to secondary hyperpara-thyroidism that then facilitates the entry of calcium and toxic heavy metals into the brain. Methods We analyzed indices of calcium metabolism plus blood-serum, urine, nail, and hair heavy metal concentrations in 12 patients with Guamanian neurodegenerative disease and 12 Chamorro control subjects. Results All 12 patients with Guamanian neurodegenerative disease had normal values for serum total and ionized calcium, 25-hydroxyvitamin D, and 24-hour urine collections for calcium. Eleven of 12 patients had normal serum parathyroid hormone values and alkaline phosphatase levels. No patient had reduced serum phosphorus or magnesium values although a minority of patients and controls had low urinary magnesium concentrations. Median blood-serum and 24–hour urine collections for heavy metals (aluminum, arsenic, cadmium, copper, iron, lead, manganese, mercury, and zinc) were statistically similar in the patient and control groups except for a slight elevation of blood, but not urine, lead in the patient group. Concentrations of heavy metals in hair and nails were similar in the two groups. Conclusions We could find no evidence in support of abnormalities of calcium metabolism or heavy metal absorption as a major causative factor in the development of neurodegenerative disease on the island of Guam.
关岛南部的肌萎缩侧索硬化症/帕金森病-痴呆症：正在消失吗？
影响因子：
--
作者：
Lavine,L;Steele,JC;Wolfe,N;Calne,DB;O'Brien,PC;Williams,DB;Kurland,LT;Schoenberg,BS
通讯作者：
Schoenberg,BS
影响因子：
56.9
作者：
PERL, DP;GAJDUSEK, DC;GIBBS, CJ
通讯作者：
GIBBS, CJ