Long-term effects of prenatal infection on the human brain: a prospective multimodal neuroimaging study.
Long-term effects of prenatal infection on the human brain: a prospective multimodal neuroimaging study.
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DOI：
10.1038/s41398-023-02597-x
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发表时间：
2023-10-03
影响因子：
6.8
通讯作者：
Bergink, Veerle
中科院分区：
文献类型：
--
作者：
Suleri, Anna;Cecil, Charlotte;Rommel, Anna-Sophie;Hillegers, Manon;White, Tonya;de Witte, Lot D.;Muetzel, Ryan L.;Bergink, Veerle
来自啮齿动物研究的有力证据表明，产前感染会影响后代的大脑，但在人类中的证据有限。在此，我们评估了孕期每个阶段常见感染的发生情况，并检验了其与青少年后代大脑发育结果的关联。我们的研究嵌套在Generation R研究中，这是一个大规模的、社会人口统计学多样的前瞻性出生队列。我们纳入了1094对母子，并研究了大脑形态（结构磁共振成像）、白质微观结构（弥散张量成像）和功能连接性（功能磁共振成像），作为14岁时的结果。我们关注整体区域和局部区域。为了定义产前感染，我们根据孕期每个阶段感染的数量和类型制定了一个评分。模型针对若干混杂因素进行了调整。我们发现产前感染与大脑白质体积呈负相关（B = -0.069，95%置信区间为 -0.123至 -0.015，p = 0.011），并且我们发现产前感染评分较高与大脑几个额颞区域体积较小之间存在关联。经过多重检验校正后，我们仅观察到产前感染与尾侧前扣带回体积之间存在关联（B = -0.104，95%置信区间为 -0.164至 -0.045，p < 0.001）。我们没有观察到产前感染对青少年大脑形态、白质微观结构或功能连接性的其他指标产生影响，这令人欣慰。我们的结果显示了未来研究中大脑的潜在关注区域；需要有关严重产前感染对人类后代大脑影响的数据。
There is convincing evidence from rodent studies suggesting that prenatal infections affect the offspring’s brain, but evidence in humans is limited. Here, we assessed the occurrence of common infections during each trimester of pregnancy and examined associations with brain outcomes in adolescent offspring. Our study was embedded in the Generation R Study, a large-scale sociodemographically diverse prospective birth cohort. We included 1094 mother-child dyads and investigated brain morphology (structural MRI), white matter microstructure (DTI), and functional connectivity (functional MRI), as outcomes at the age of 14. We focused on both global and focal regions. To define prenatal infections, we composed a score based on the number and type of infections during each trimester of pregnancy. Models were adjusted for several confounders. We found that prenatal infection was negatively associated with cerebral white matter volume (B = −0.069, 95% CI −0.123 to −0.015, p = 0.011), and we found an association between higher prenatal infection scores and smaller volumes of several frontotemporal regions of the brain. After multiple testing correction, we only observed an association between prenatal infections and the caudal anterior cingulate volume (B = −0.104, 95% CI −0.164 to −0.045, p < 0.001). We did not observe effects of prenatal infection on other measures of adolescent brain morphology, white matter microstructure, or functional connectivity, which is reassuring. Our results show potential regions of interest in the brain for future studies; data on the effect of severe prenatal infections on the offspring’s brain in humans are needed.
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影响因子：
6.2
作者：
Cordeiro CN;Tsimis M;Burd I
通讯作者：
Burd I
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
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O'Sullivan MJ
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Bilbo SD;Block CL;Bolton JL;Hanamsagar R;Tran PK
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