Temporal association in hospitalizations for tuberculosis, invasive pneumococcal disease and influenza virus illness in South African children.
Temporal association in hospitalizations for tuberculosis, invasive pneumococcal disease and influenza virus illness in South African children.
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DOI：
10.1371/journal.pone.0091464
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Madhi SA
中科院分区：
文献类型：
--
作者：
Dangor Z;Izu A;Moore DP;Nunes MC;Solomon F;Beylis N;von Gottberg A;McAnerney JM;Madhi SA
结核病住院的季节性变化可能部分与叠加的细菌或易感呼吸道病毒感染有关。我们的目的是研究南非儿童因培养证实的肺结核（PTB）、侵袭性肺炎球菌病（IPD）和流感病毒流行而住院的时间相关性。我们进行了一项回顾性分析，检查了2005年至2008年与南非索韦托流感流行有关的儿童中因文化证实的肺结核和IPD住院的季节性趋势。采用X-11季节调整方法，将流感病毒流行、肺结核和肺炎住院率的原始时间序列分解为趋势周期分量、季节分量和不规则分量。为了比较三个系列的季节性，趋势和不规则成分被去除，只检查季节性成分。在整个研究期间，流感病毒流行在5月至7月（冬季）达到高峰，紧随其后的是IPD（8月至10月）和PTB（8月至11月）住院率的增加。与儿童结核病住院治疗相关的年内和年间时间变化可能部分由影响肺炎球菌疾病时间变化的因素驱动，包括温带气候中流感病毒流行严重程度的潜在差异。宿主和这些感染因子之间相互作用的动力学似乎是复杂和多因素的。
The seasonal variability in hospitalization for tuberculosis may in part relate to super-imposed bacterial or predisposing respiratory viral infections. We aimed to study the temporal association between hospitalization for culture-confirmed pulmonary tuberculosis (PTB), invasive pneumococcal disease (IPD) and influenza virus epidemics in South African children. We undertook a retrospective analysis which examined seasonal trends, from 2005 to 2008, for hospitalization for culture-confirmed PTB and IPD among children in relation to the influenza epidemics in Soweto, South Africa. Original time-series of the influenza virus epidemics and hospitalization rates for PTB and IPD were decomposed into three components: a trend cycle component, a seasonal component and an irregular component using the X-11 seasonal adjustment method. To compare the seasonality amongst the three series, the trend and irregular components were removed and only seasonal components examined. Across the study period, the influenza virus epidemics peaked during May to July (winter) months, which was closely followed by an increase in the incidence of hospitalization for IPD (August to October) and PTB (August to November). Within- and between-year temporal changes associated with childhood TB hospitalization may in part be driven by factors which influence temporal changes in pneumococcal disease, including potential variability in the severity of influenza virus epidemics in temperate climates. The dynamics of the interplay between the host and these infectious agents appears to be complex and multifactorial.
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影响因子：
5.5
作者：
Klugman, Keith P.;Chien, Yu-Wen;Madhi, Shabir A.
通讯作者：
Madhi, Shabir A.
DOI：
10.1086/591708
发表时间：
2008-10-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Morens DM;Taubenberger JK;Fauci AS
通讯作者：
Fauci AS
影响因子：
5.5
作者：
Noymer, Andrew
通讯作者：
Noymer, Andrew
影响因子：
3.6
作者：
Moore, David P.;Klugman, Keith P.;Madhi, Shabir A.
通讯作者：
Madhi, Shabir A.
影响因子：
3.6
作者：
Madhi, Shabir A.;Ludewick, Herbert;Klugman, Keith P.
通讯作者：
Klugman, Keith P.