Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner.
Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner.
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DOI：
10.1093/jleuko/qiad053
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发表时间：
2023-09-27
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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衰老与全身性炎症（炎症）的加剧和免疫系统功能的进行性丧失（免疫衰老）有关。白细胞迁移是有效免疫所必需的;然而，白细胞向组织中的运输失调有助于炎症和年龄相关性炎性疾病的发展。衰老调节炎症条件下的白细胞运输，然而，老化是否调节稳态条件下的白细胞运输仍有待阐明。虽然免疫反应明显具有性别二态性，但有限的研究调查了性别对白细胞运输过程中年龄相关变化的影响。在这里，我们研究了稳态下年轻（3个月），中年（18个月）和老年（21个月）雄性和雌性野生型小鼠腹腔内白细胞群的年龄相关性和性别特异性变化。我们发现雌性小鼠腹腔内白细胞数量呈年龄相关性增加，主要是B细胞，这可能反映了随着年龄的增长，通过该组织的运输增加。这伴随着老年腔体内炎症环境的增加，包括化学引诱物水平的增加，包括B细胞化学引诱物CXCL 13和CCL 21、可溶性粘附分子和促炎细胞因子，这在老年雌性小鼠中更为明显。活体显微镜技术显示血管结构改变和老年雌性小鼠腹膜内的血管通透性增加，这可能支持随着年龄的增长白细胞向腹腔的运输增加。总之，这些数据表明，老化影响稳态白细胞运输过程中的性别特异性的方式。
Aging is associated with exacerbated systemic inflammation (inflammaging) and the progressive loss of immune system function (immunosenescence). Leukocyte migration is necessary for effective immunity; however, dysregulated trafficking of leukocytes into tissue contributes to inflammaging and the development of age-related inflammatory diseases. Aging modulates leukocyte trafficking under inflammatory conditions; however, whether aging modulates leukocyte trafficking under homeostatic conditions remains to be elucidated. Although immune responses are evidently sexually dimorphic, limited studies have investigated the effect of sex on age-related changes to leukocyte trafficking processes. Here, we investigated age-related and sex-specific changes to the leukocyte populations within the peritoneal cavity of young (3-mo), middle-aged (18-mo) and old (21-mo) male and female wild-type mice in the steady state. We found an age-related increase in the number of leukocytes within the peritoneal cavity of female mice, predominantly B cells, which may reflect increased trafficking through this tissue with age. This was accompanied by an increased inflammatory environment within the aged cavity, including increased levels of chemoattractants, including B cell chemoattractants CXCL13 and CCL21, soluble adhesion molecules, and proinflammatory cytokines, which was more pronounced in aged female mice. Intravital microscopy techniques revealed altered vascular structure and increased vascular permeability within the peritoneal membrane of aged female mice, which may support increased leukocyte trafficking to the cavity with age. Together, these data indicate that aging affects homeostatic leukocyte trafficking processes in a sex-specific fashion.
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DOI：
10.1111/jon.13023
发表时间：
2022-09
期刊：
Journal of neuroimaging : official journal of the American Society of Neuroimaging
影响因子：
--
作者：
通讯作者：
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影响因子：
20.3
作者：
Hao, Yi;O'Neill, Patrick;Cancro, Michael P.
通讯作者：
Cancro, Michael P.
影响因子：
5.3
作者：
Fulop, T;Fouquet, C;Dupuis, G
通讯作者：
Dupuis, G
影响因子：
7.2
作者：
Tran, Tri M.;Temkin, Vladislav;Shi, Bo;Pagliari, Lisa;Daniel, Soizic;Ferran, Christiane;Pope, Richard M.
通讯作者：
Pope, Richard M.
影响因子：
7.3
作者：
通讯作者：
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