The Technological Parameter Optimization of Rapid Freeze Prototyping for 3D Tissue Scaffold Fabrication
The Technological Parameter Optimization of Rapid Freeze Prototyping for 3D Tissue Scaffold Fabrication
复制标题
3D 组织支架制造快速冷冻原型技术参数优化
作者:
Dali Liu;Yuanyuan Liu;Changjuan Jing;Qianggao Wang;Qingwei Li;Qingxi Hu
When using the Rapid freeze prototype (RFP) process to fabricate 3D tissue bone scaffold, the selecting of technological parameters directly affects lap ratio, which is the foundation of continuous fabrication and scaffold quality. Through analyzing the force of non-solidified fiber, Velocity ratio, liquid temperature, solid content, nozzle diameter and row spacing have been chosen as the influence factors and the L16 (45) orthogonal experiments have been done The experiments result is that material viscosity and row spacing is the most important factors for lap ratio influence. Optimal parameters combination has been got by range analysis. Finally, the mixed solution of gelatin-chitosan experiment with the optimal parameters has successfully produced multilayer tissue bone scaffold, including multiple scale structure. Streszczenie. W artykule zaprezentowano process wytwarzania materialow trojwymiarowych metoda gwaltownego oziebiania - RFP (rapid freeze prototype). Materialem wyjściowym jest mieszanina zelatyny i chitozanu. Na proces tworzenia struktury ma wplyw wiele czynnikow, takich jak: temperatura cieczy, zawartośc skladnika stalego, rozmiary wezlow, średnica i odstepy miedzy rzedami. (Optymalizacja parametrow technologicznych przy wytwarzaniu struktur trojwymiarowych metoda RFP)
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DOI:
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发表时间:
2002
期刊:
--
影响因子:
--
作者:
Feng Chao
通讯作者:
Feng Chao
影响因子:
6
作者:
Z. Xiong;Yongnian Yan;Renji Zhang;Lei Sun
通讯作者:
Z. Xiong;Yongnian Yan;Renji Zhang;Lei Sun
DOI:
10.1115/1.3173804
发表时间:
2009-08
影响因子:
4
作者:
F. D. Bryant;M. Leu
通讯作者:
F. D. Bryant;M. Leu
DOI:
10.1002/1097-4636(200105)55:2
发表时间:
2001-05
期刊:
Journal of biomedical materials research
影响因子:
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作者:
D. W. Hutmacher;Thorsten Schantz;I. Zein;K. Ng;S. Teoh;K. C. Tan
通讯作者:
D. W. Hutmacher;Thorsten Schantz;I. Zein;K. Ng;S. Teoh;K. C. Tan
影响因子:
--
作者:
Jin Le
通讯作者:
Jin Le