The effects of native whey and α-lactalbumin on the social and individual behaviour of C57BL/6J mice.
The effects of native whey and α-lactalbumin on the social and individual behaviour of C57BL/6J mice.
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天然乳清和 α-乳清蛋白对 C57BL/6J 小鼠社会和个体行为的影响。
DOI：
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发表时间：
2013
影响因子：
3.6
通讯作者：
R. Korpela
中科院分区：
文献类型：
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作者：
O. Vekovischeva;K. Peuhkuri;P. Bäckström;N. Sihvola;T. Pilvi;R. Korpela
牛奶蛋白是日常喂养的主要成分，并显示出改变精神状况的潜力。然而，长期使用牛奶蛋白的影响仍然知之甚少。本研究的目的是比较两种乳清蛋白（α-乳白蛋白（α-lac）和天然乳清）与酪蛋白对小鼠社会和个体行为的影响。在为期30天的饮食干预期间，雄性C57 BL/6 J小鼠随意获得含有17%（w/w）的三种蛋白质来源之一的实验饮食：α-紫胶、天然乳清或酪蛋白。小鼠自愿接近一个转轮。在基线和干预结束时测试社会行为（群体和居民入侵者活动）。每个饮食组的一半，然后退出饮食和运行轮7天，社会活动和个人行为测试（开放领域，高架十字迷宫，光暗盒和强迫游泳）进行，以评估焦虑和抑郁样状态。研究表明，与酪蛋白相比，长期摄入乳清蛋白可能会调节行为。富含乳糖的饮食表现出抗焦虑和抗抑郁活性，而乳清饮食改善了社交能力。饮食组之间的差异在跑步轮和实验饮食的撤回下是明显的，这表明牛奶蛋白的有益效果在压力情况下更明显。饮食诱导的行为变化在喂食后一周内仍然可见，这表明乳清部分的蛋白质对小鼠的精神状态具有延长的功效。
Milk proteins are the main components of everyday feeding and demonstrate a promising potential to change the mental condition. However, the effects of milk proteins after prolonged use remain poorly understood. The aim of the present study was to compare the effects of two whey proteins (alpha-lactalbumin (alpha-lac) and native whey) with casein on social and individual behaviour in mice. During a 30 d-long dietary intervention, male C57BL/6J mice had ad libitum access to an experimental diet containing 17% (w/w) of one of three protein sources: a-lac, native whey or casein. Mice had voluntary access to a running wheel. Social behaviour (group and resident-intruder activity) was tested at baseline and at the end of the intervention. Half of each dietary group was then withdrawn from the diet and running wheel for 7 d, and social activity and individual behaviour tests (open field, elevated-plus maze, light–dark box and forced swimming) were performed, to evaluate anxiety and depression-like status. The study shows that the long-term ingestion of whey proteins may modulate behaviour when compared with casein. Diet enriched with a-lac exhibited anxiolytic and antidepressive activities while the whey diet improved sociability. The differences between the diet groups were pronounced under the running wheel and the withdrawal of the experimental diet, suggesting that the beneficial effects of the milk proteins are clearer in stressful situations. Diet-induced behavioural changes remained visible for a week after feeding, which suggests that the proteins of the milk whey fraction have prolonged efficacy on the mental state of mice.
影响因子：
2.3
作者：
Ozburn, Angela Renee;Harris, R. Adron;Blednov, Yuri A.
通讯作者：
Blednov, Yuri A.