Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domain.
Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domain.
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DOI：
10.3389/fcell.2023.1328806
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发表时间：
2023
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
基因组印记是一种表观遗传过程，其中基因以亲本特异性方式单等位表达。印记基因经常被发现聚集在基因组中，这可能说明它们需要共享的调控控制和功能上的相互依赖。 Dlk1-Dio3 结构域是最大的印记簇之一。该区域的基因参与发育、行为和产后代谢：未能正确调节该区域会导致人类出现 Kagami-Ogata 或 Temple 综合征。该区域包含许多其他印记结构域的特征，例如长非编码 RNA 和亲本起源特异性 CTCF 结合。最近的研究表明，Dlk1-Dio3 结构域通过二分印记控制区 (ICR) 进行精细调节，该控制区在两个亲本染色体上发挥不同的功能以建立单等位基因表达。此外，Dlk1 基因在神经源性生态位中选择性地缺失印记，这说明在不同组织中需要对该结构域进行精确的剂量调节。在这里，我们讨论以下内容：配子中的差异表观遗传标记如何引起一系列事件，从而导致该区域的印记，这种机制如何在神经源性生态位中选择性关闭，以及为什么研究这个印记区域为我们如何思考基因组功能的分层表观遗传控制增加了一层复杂性。
Genomic imprinting is an epigenetic process whereby genes are monoallelically expressed in a parent-of-origin-specific manner. Imprinted genes are frequently found clustered in the genome, likely illustrating their need for both shared regulatory control and functional inter-dependence. The Dlk1-Dio3 domain is one of the largest imprinted clusters. Genes in this region are involved in development, behavior, and postnatal metabolism: failure to correctly regulate the domain leads to Kagami–Ogata or Temple syndromes in humans. The region contains many of the hallmarks of other imprinted domains, such as long non-coding RNAs and parental origin-specific CTCF binding. Recent studies have shown that the Dlk1-Dio3 domain is exquisitely regulated via a bipartite imprinting control region (ICR) which functions differently on the two parental chromosomes to establish monoallelic expression. Furthermore, the Dlk1 gene displays a selective absence of imprinting in the neurogenic niche, illustrating the need for precise dosage modulation of this domain in different tissues. Here, we discuss the following: how differential epigenetic marks laid down in the gametes cause a cascade of events that leads to imprinting in the region, how this mechanism is selectively switched off in the neurogenic niche, and why studying this imprinted region has added a layer of sophistication to how we think about the hierarchical epigenetic control of genome function.
影响因子：
3.9
作者：
Gagne A;Hochman A;Qureshi M;Tong C;Arbon J;McDaniel K;Davis TL
通讯作者：
Davis TL
影响因子：
4
作者：
Pauler, Florian M.;Barlow, Denise P.;Hudson, Quanah J.
通讯作者：
Hudson, Quanah J.