Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels.
Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels.
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DOI：
10.3389/fphys.2018.00095
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发表时间：
2018
影响因子：
4
通讯作者：
Pariente JA
中科院分区：
文献类型：
--
作者：
Carrasco C;Naziroǧlu M;Rodríguez AB;Pariente JA
目前，神经性疼痛是一个被低估的社会经济健康问题，影响着全球数百万人，由于癌症和糖尿病等多种疾病的慢性化，其发病率在未来几年可能会增加。越来越多的证据将存在于几种疾病中的神经性疼痛联系起来[即，脊髓损伤（SCI）、癌症、糖尿病和酒精中毒]到中枢致敏，作为由氧化和亚硝化应激诱导的线粒体功能障碍的总体结果。此外，炎症信号和细胞内钙离子超载也可能涉及这个复杂的网络，尚未阐明。近年来，钙通道即瞬时受体电位（transient receptor potential，TRP）超家族，包括A（TRAP 1）、M（TRPM 2和7）和V（TRPV 1和4）亚家族成员，被证实在感觉神经元介导的伤害性感受中发挥作用。因此，由于神经性疼痛可能是活性氧和内源性抗氧化剂之间失衡的结果，因此补充抗氧化剂可能是一种治疗选择。这种疗法将通过抗氧化和免疫调节功能发挥其有益作用，优化线粒体功能，甚至增加这一重要细胞器的生物合成;总的来说，抗氧化剂补充剂将改善患者的生活质量。本文旨在加深对神经病理性疼痛的认识，总结临床情况和可能的原因，氧化应激，线粒体功能障碍和TRP通道激活之间存在的关系，以及与抗氧化剂补充相关的科学证据。
Currently, neuropathic pain is an underestimated socioeconomic health problem affecting millions of people worldwide, which incidence may increase in the next years due to chronification of several diseases, such as cancer and diabetes. Growing evidence links neuropathic pain present in several disorders [i.e., spinal cord injury (SCI), cancer, diabetes and alcoholism] to central sensitization, as a global result of mitochondrial dysfunction induced by oxidative and nitrosative stress. Additionally, inflammatory signals and the overload in intracellular calcium ion could be also implicated in this complex network that has not yet been elucidated. Recently, calcium channels namely transient receptor potential (TRP) superfamily, including members of the subfamilies A (TRAP1), M (TRPM2 and 7), and V (TRPV1 and 4), have demonstrated to play a role in the nociception mediated by sensory neurons. Therefore, as neuropathic pain could be a consequence of the imbalance between reactive oxygen species and endogen antioxidants, antioxidant supplementation may be a treatment option. This kind of therapy would exert its beneficial action through antioxidant and immunoregulatory functions, optimizing mitochondrial function and even increasing the biogenesis of this vital organelle; on balance, antioxidant supplementation would improve the patient's quality of life. This review seeks to deepen on current knowledge about neuropathic pain, summarizing clinical conditions and probable causes, the relationship existing between oxidative stress, mitochondrial dysfunction and TRP channels activation, and scientific evidence related to antioxidant supplementation.
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DOI：
10.1073/pnas.0902675106
发表时间：
2009-11-24
影响因子：
11.1
作者：
Chuang, Huai-hu;Lin, Stephanie
通讯作者：
Lin, Stephanie
影响因子：
3.3
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影响因子：
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作者：
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影响因子：
2.9
作者：
Al Moundhri, Mansour S.;Al-Salam, Suhail;Ali, Badreldin H.
通讯作者：
Ali, Badreldin H.
影响因子：
3.6
作者：
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通讯作者：
Pariente, Jose A.