Zinc-triggered hydrogelation of a self-assembling β-hairpin peptide.
Zinc-triggered hydrogelation of a self-assembling β-hairpin peptide.
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DOI：
10.1002/anie.201006652
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发表时间：
2011-02-11
期刊：
影响因子：
--
通讯作者：
Schneider JP
中科院分区：
文献类型：
--
作者：
Micklitsch CM;Knerr PJ;Branco MC;Nagarkar R;Pochan DJ;Schneider JP
通过肽自组装形成的环境响应性水凝胶导致具有限定结构和用途的材料用于广泛的生物医学应用。[1]通过金属离子与肽的络合形成结构确定的材料一直是特别感兴趣的。在自然界中，金属与组氨酸、甲硫氨酸、半胱氨酸、天冬氨酸和谷氨酸残基的相互作用被用来诱导蛋白质的构象变化，以驱动各种生物反应并形成超分子结构。[2]已经开发了肽以利用这些天然存在的配体来增强结构稳定性并促进与各种金属阳离子结合时的自组装。[3]此外，非天然的金属连接残基已被合成，作为触发器的高阶组装。[4]锌是参与细胞复制、蛋白质合成和细胞外重塑的转录因子和酶的重要辅因子。[5，6]在伤口修复中，锌促进受损组织部位的基质金属蛋白酶清创和角质形成细胞迁移。[6，7]局部施用锌可增强急性和慢性伤口的愈合。[8]此外，锌可以抑制几种细菌的生长，从而有助于防止伤口感染。[9]因此，开发含有锌的生物材料作为伤口敷料将是有益的，有助于增强愈合过程并降低感染风险。
Environmentally responsive hydrogels formed by peptide self-assembly lead to materials with defined structure and utility for a wide range of biomedical applications.[1] The formation of structurally defined materials through the complexation of metal ions by peptides has been of particular interest. In nature, interactions of metals with histidine, methionine, cysteine, aspartic acid, and glutamic acid residues are utilized to induce conformational changes in proteins to drive diverse biological reactions and to form supramolecular structures.[2] Peptides have been developed to take advantage of these naturally occurring ligands to enhance structural stability and promote self-assembly on binding to a variety of metal cations.[3] Additionally, non-natural metal-ligating residues have been synthesized to serve as triggers for higher-order assembly.[4]Zinc is an essential cofactor in transcription factors and enzymes involved in cell replication, protein synthesis, and extracellular remodeling.[5, 6] In wound repair, zinc promotes matrix metalloproteinase debridement and keratinocyte migration at the site of damaged tissue.[6, 7] Topical administration of zinc results in the enhanced healing of both acute and chronic wounds.[8] In addition, zinc can inhibit the growth of several bacterial species, and thus can help to prevent infection in wound beds.[9] Therefore, the development of biomaterials incorporating zinc would be beneficial as wound dressings that help augment the healing process and lower the risk of infection.
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影响因子：
41.2
作者：
通讯作者：
--
影响因子：
2.9
作者：
LENZ, GR;MARTELL, AE
通讯作者：
MARTELL, AE
DOI：
10.1073/pnas.0702669104
发表时间：
2007-08-14
影响因子：
11.1
作者：
Dong, Jijun;Canfield, Jeffrey M.;Lynn, David G.
通讯作者：
Lynn, David G.
影响因子：
3.3
作者：
Naskar, Jishu;Palui, Goutam;Banerjee, Arindam
通讯作者：
Banerjee, Arindam
影响因子：
15
作者：
Ma, Manlung;Kuang, Yi;Xu, Bing
通讯作者：
Xu, Bing