Pathological correlates of impaired self-awareness of memory function in Alzheimer's disease.
Pathological correlates of impaired self-awareness of memory function in Alzheimer's disease.
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DOI：
10.1186/s13195-021-00856-x
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发表时间：
2021-06-25
期刊：
影响因子：
--
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Gagliardi G;Kuppe M;Lois C;Hanseeuw B;Vannini P;Alzheimer’s Disease Neuroimaging Initiative
记忆功能的自我意识受损，又称失认症，是阿尔茨海默病 (AD) 的常见症状；然而，其病理相关性仍不清楚。在这里，我们研究了淀粉样蛋白和 tau 蛋白对记忆自我意识的影响。 ADNI 队列中包括 236 名临床正常 (N) 和 102 名临床受损 (I) 参与者。使用正电子发射断层扫描 (PET) 评估淀粉样蛋白（整体）和 tau 蛋白负荷（内嗅和颞下皮质）。使用参与者主观评分的差异指数以及参与者客观记忆表现评分来评估记忆的自我意识。主观和客观值来自日常认知记忆问卷和逻辑记忆（延迟回忆）。与 N 组相比，I 组对记忆功能的较低认识（两种方法）与较高的病理水平相关。tau 蛋白病对个体主诉有显着影响，但淀粉样变性没有显着影响，因此较高水平的 tau 蛋白与较低的认识相关。在与 AD 生物标志物相关的疾病的演变过程中，自我意识受损逐渐出现。不一致的主观和客观测量对于临床考虑可能很重要。在线版本包含可在 10.1186/s13195-021-00856-x 获取的补充材料。
Impaired self-awareness of memory function, a.k.a. anosognosia, is a common symptom in Alzheimer’s disease (AD); however, its pathological correlates remain unclear. Here, we investigated the impact of amyloid and tau on memory self-awareness. Two hundred thirty-six clinically normal (N) and 102 impaired (I) participants from the ADNI cohort were included. Amyloid (global) and tau burden (in entorhinal and inferior temporal cortices) were assessed using positron emission tomography (PET). Self-awareness of memory was assessed using discrepancy indexes of subjective participant-informant ratings, as well as participant-objective scores of memory performance. Subjective and objective values were derived from the Everyday Cognition memory questionnaire and Logical Memory (delayed recall). Lower awareness (both methods) of memory function was associated with higher levels of pathology in the I group as compared to N. There was a significant effect of tauopathy, but not amyloidosis, on individual complaint, such that higher levels of tau associated with lower awareness. Impaired self-awareness appears progressively in the evolution of the disease related to AD biomarkers. Discordant subjective and objective measures may be important for clinical consideration. The online version contains supplementary material available at 10.1186/s13195-021-00856-x.
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影响因子：
11.2
作者：
Landau, Susan M.;Mintun, Mark A.;Joshi, Abhinay D.;Koeppe, Robert A.;Petersen, Ronald C.;Aisen, Paul S.;Weiner, Michael W.;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
2.6
作者：
Amariglio RE;Becker JA;Carmasin J;Wadsworth LP;Lorius N;Sullivan C;Maye JE;Gidicsin C;Pepin LC;Sperling RA;Johnson KA;Rentz DM
通讯作者：
Rentz DM
影响因子：
3.8
作者：
Bauer, DJ;Curran, PJ
通讯作者：
Curran, PJ
影响因子：
120.7
作者：
Jansen, Willemijn J.;Ossenkoppele, Rik;Knol, Dirk L.;Tijms, Betty M.;Scheltens, Philip;Verhey, Frans R. J.;Visser, Pieter Jelle
通讯作者：
Visser, Pieter Jelle
影响因子：
29
作者：
Hanseeuw, Bernard J.;Betensky, Rebecca A.;Johnson, Keith
通讯作者：
Johnson, Keith