Fine-tuning immune surveillance by fever-range thermal stress.
Fine-tuning immune surveillance by fever-range thermal stress.
复制标题
DOI：
10.1007/s12026-009-8122-9
复制
发表时间：
2010-03
影响因子：
4.4
通讯作者：
Evans SS
中科院分区：
文献类型：
--
作者：
Fisher DT;Vardam TD;Muhitch JB;Evans SS
An effectively orchestrated immune response to infection and disease depends on efficient trafficking of lymphocytes across vascular beds at distinct tissue sites. Local inflammation and systemic fever increase immune surveillance to immune-relevant sites throughout the body. During the initiation phase of inflammation, this tightly-regulated process improves leukocyte trafficking to the secondary lymphoid organs where they undergo activation and expansion in response to cognate antigen. In the resolution phase following the clearance of the invading pathogen, lymphocyte entry is rapidly returned to baseline conditions. Specialized blood vessels termed high endothelial venules (HEVs) have emerged as critical ‘hotspots’ controlling the rate of lymphocyte entry into lymphoid organs during both phases of inflammation. In this review we will examine the remarkably tight regulation of lymphocyte trafficking across HEVs conferred by inflammatory cues associated with the thermal element of fever. These studies have revealed a novel role for interleukin-6 (IL-6) trans-signaling in eliciting systemic effects on lymphocyte trafficking patterns to fine-tune immune surveillance.
登录
查看更多内容
DOI：
10.1084/jem.20001021
发表时间：
2002-03-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blattman JN;Antia R;Sourdive DJ;Wang X;Kaech SM;Murali-Krishna K;Altman JD;Ahmed R
通讯作者：
Ahmed R
影响因子：
3.1
作者：
Evans, Sharon S.;Fisher, Daniel T.;Chen, Qing
通讯作者：
Chen, Qing
影响因子：
4.1
作者：
KAMATA, T;PUZON, W;TAKADA, Y
通讯作者：
TAKADA, Y
影响因子：
3
作者：
Ahlers, O;Hildebrandt, B;Kerner, T
通讯作者：
Kerner, T
DOI：
10.1080/10739680802353850
发表时间：
2009-02
期刊：
Microcirculation (New York, N.Y. : 1994)
影响因子：
--
作者：
Chen Q;Appenheimer MM;Muhitch JB;Fisher DT;Clancy KA;Miecznikowski JC;Wang WC;Evans SS
通讯作者：
Evans SS