Functional alteration patterns of default mode networks: comparisons of normal aging, amnestic mild cognitive impairment and Alzheimer's disease.
Functional alteration patterns of default mode networks: comparisons of normal aging, amnestic mild cognitive impairment and Alzheimer's disease.
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DOI：
10.1111/ejn.12177
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Lee JM
中科院分区：
文献类型：
--
作者：
Cha J;Jo HJ;Kim HJ;Seo SW;Kim HS;Yoon U;Park H;Na DL;Lee JM
大多数针对遗忘性轻度认知障碍（aMCI）和阿尔茨海默病（AD）患者的默认模式网络（DMN）研究仅基于比较两组，即患者和对照组。同时比较三组（正常组、aMCI 组和 AD 组）获得的信息可能会让我们更好地了解痴呆症的进展。本研究的目的是评估 DMN 在从正常到 aMCI 到 AD 的连续体中的功能连接。使用独立成分分析比较三组之间功能连接的差异。使用简易精神状态检查（MMSE）评分的多元回归分析研究功能连接与疾病进展之间的关系。结果揭示了左后扣带皮层（PCC）、左颞中回（MTG）、右额中回（MFG）和双侧海马旁回（PHG）的差异。与健康受试者相比，aMCI 和 AD 患者的左侧 PCC 和左侧 PHG 的连接性均降低。此外，AD 患者的左侧 MTG 和右侧 PHG 的连通性也降低。与其他组相比，AD 患者右侧 MFG 的功能连接有所增加。 MMSE 评分与 PCC、MTG 和 MFG 区域的功能连接表现出显着的正相关和负相关。总而言之，AD 患者 MFG 功能连接的增加可能通过皮质-皮质连接的补偿机制来补偿 PCC、MTG 功能的丧失。
Most of default mode network (DMN) studies in patient with amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) were based only on the comparing two groups, namely patients and controls. Information derived from comparing the three groups, normal, aMCI, and AD group, simultaneously may lead us to better understand the progression of dementia. The purpose of this study was to evaluate functional connectivity of DMN in the continuum from normal through aMCI to AD. Differences in functional connectivity were compared between the three groups using independent component analysis. The relationship between the functional connectivity and disease progression was investigated using multiple regression analysis with Mini-Mental State Examination (MMSE) scores. The results revealed differences throughout the left posterior cingulate cortex (PCC), left middle temporal gyrus (MTG), right middle frontal gyrus (MFG), and bilateral parahippocampal gyrus (PHG). Both patients with aMCI and AD showed decreased connectivity in the left PCC and left PHG compared with healthy subjects. Furthermore, patient with AD also showed decreased connectivity in the left MTG and right PHG. Increased functional connectivity was observed in the right MFG of patients with AD compared with other groups. MMSE scores exhibited significant positive and negative correlations with functional connectivity in PCC, MTG and MFG regions. Taken together, an increased functional connectivity in the MFG for AD patients might compensate for the loss of function in the PCC, MTG via compensatory mechanisms in cortico-cortical connections.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
5.7
作者：
Herholz, K;Salmon, E;Heiss, WD
通讯作者：
Heiss, WD
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
16.2
作者：
Logan, JM;Sanders, AL;Buckner, RL
通讯作者：
Buckner, RL
影响因子：
5.7
作者：
Fransson, Peter;Marrelec, Guillaume
通讯作者：
Marrelec, Guillaume