New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.
New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.
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DOI：
10.1371/journal.pone.0009723
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发表时间：
2010-03-18
期刊：
影响因子：
3.7
通讯作者：
Ikegawa S
中科院分区：
文献类型：
--
作者：
Nakajima M;Takahashi A;Kou I;Rodriguez-Fontenla C;Gomez-Reino JJ;Furuichi T;Dai J;Sudo A;Uchida A;Fukui N;Kubo M;Kamatani N;Tsunoda T;Malizos KN;Tsezou A;Gonzalez A;Nakamura Y;Ikegawa S
骨关节炎(OA)是一种常见的疾病，具有一定的遗传成分。然而，只有少数几个有明确功能证据和相关性复制的OA易感基因已被报道。通过全基因组关联研究和对总共4,800名日本受试者的复制，我们确定了两个单核苷酸多态(SNPs)(rs7775228和rs10947262)与膝骨性关节炎的易感性相关。这两个SNP位于一个含有HLAII/III类基因的区域，其关联达到全基因组意义(rs7775228的P = 为2.43×10−8，rs10947262为6.73×10−8)。我们的结果提示免疫学机制参与了骨性关节炎的发病机制。
Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ∼4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10−8 for rs7775228 and 6.73×10−8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.
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影响因子：
30.8
作者：
Kizawa, H;Kou, I;Ikegawa, S
通讯作者：
Ikegawa, S
影响因子：
27.4
作者：
PATTRICK, M;MANHIRE, A;DOHERTY, M
通讯作者：
DOHERTY, M
影响因子：
5.5
作者：
Moos, V;Menard, J;Müller, B
通讯作者：
Müller, B
影响因子：
3.5
作者：
Mototani, H;Mabuchi, A;Ikegawa, S
通讯作者：
Ikegawa, S
影响因子：
--
作者：
Evans, TI;Han, JF;Moxley, G
通讯作者：
Moxley, G