Somatostatin receptor activation is involved in the control of daily torpor in a seasonal mammal.
Somatostatin receptor activation is involved in the control of daily torpor in a seasonal mammal.
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生长抑素受体激活参与季节性哺乳动物日常麻木状态的控制
DOI：
10.1152/ajpregu.00191.2015
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Barrett P
中科院分区：
文献类型：
--
作者：
Scherbarth F;Diedrich V;Dumbell RA;Schmid HA;Steinlechner S;Barrett P
西伯利亚仓鼠（Phodopus sungorus）在冬季样短光周期（SP）中仅在102个月后才表现出自发的每日麻痹。虽然一些SP诱导的激素变化已被证明是必要的季节性麻痹的发生，整套的先决条件仍然是未知的。最近的研究结果提供了证据表明，下丘脑垂体生长轴参与内分泌反应的SP曝光在光周期仓鼠。为了研究生长激素（GH）和胰岛素样生长因子-1（IGF-1）分泌的抑制是否会影响每日嗜睡的发生率，我们使用了两种生长抑素受体激动剂，帕瑞肽（SOM 230）和奥曲肽，对受体亚型具有不同的亲和力。与假处理对照组相比，帕瑞肽显著增加雄性仓鼠的昏睡频率，昏睡持续时间通常延长，在某些情况下超过12 h。相比之下，奥曲肽给药降低了SP仓鼠的体重，但对雄性仓鼠的麻痹频率仅有轻微影响，对雌性仓鼠无影响。连同测量的循环IGF-1的浓度，本研究结果强烈表明，GH/IGF-1轴的活性降低是不是刺激迟钝表达的关键，但激活特定的生长抑素受体是至关重要的。某些生长抑素受体亚型在麻痹诱导中的这种假定作用为阐明麻痹调节的内分泌机制提供了一种有前途的新方法。
Siberian hamsters (Phodopus sungorus) show spontaneous daily torpor only after ∼2 mo in winter-like short photoperiods (SP). Although some SP-induced hormonal changes have been demonstrated to be necessary for the occurrence of seasonal torpor, the whole set of preconditions is still unknown. Recent findings provide evidence that the hypothalamic pituitary growth axis is involved in endocrine responses to SP exposure in the photoperiodic hamsters. To examine whether suppression of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) secretion affects the incidence of daily torpor, we used two somatostatin receptor agonists, pasireotide (SOM230) and octreotide, with different affinity profiles for receptor subtypes. Pasireotide strikingly increased the torpor frequency in male hamsters compared with sham-treated controls, and torpor duration was often increased, which in some cases exceeded 12 h. In contrast, administration of octreotide reduced the body weight of SP hamsters but had only a marginal effect on torpor frequency in males and no effect in females. Together with measured concentrations of circulating IGF-1, the present results strongly suggest that reduced activity of the GH/IGF-1 axis is not critical for stimulation of torpor expression but activation of specific somatostatin receptors is critical. This putative role for certain somatostatin receptor subtypes in torpor induction provides a promising new approach to unravel the endocrine mechanisms of torpor regulation.
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影响因子：
3.2
作者：
Dumbell, R. A.;Scherbarth, F.;Barrett, P.
通讯作者：
Barrett, P.
糖尿病大鼠服用奥曲肽：对肾肥大和尿白蛋白排泄的影响。
影响因子：
19.6
作者：
A. Flyvbjerg;S. Marshall;J. Frystyk;K. W. Hansen;A. Harris;H. Orskov
通讯作者：
H. Orskov
车轮运转对正加仓鼠 (Phodopus sungorus) 光周期反应的影响
DOI：
--
发表时间：
2008
期刊：
Journal of Comparative Physiology □ B
影响因子：
--
作者：
Frank Scherbarth;I. Petri;S. Steinlechner
通讯作者：
S. Steinlechner
SOM230：一种新型生长抑素肽模拟物，对大鼠、灵长类动物和狗的生长激素/胰岛素样生长因子-I 轴具有有效的抑制作用。
影响因子：
4.8
作者：
G. Weckbecker;U. Briner;I. Lewis;C. Bruns
通讯作者：
C. Bruns
轮子转动会影响准加仓鼠 (Phodopus sungorus) 生理和形态特征的季节性适应。
DOI：
--
发表时间：
2007
期刊：
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
影响因子：
--
作者：
Frank Scherbarth;J. Rozman;M. Klingenspor;G. Brabant;S. Steinlechner
通讯作者：
S. Steinlechner