Octreotide administration in diabetic rats: effects on renal hypertrophy and urinary albumin excretion.
Octreotide administration in diabetic rats: effects on renal hypertrophy and urinary albumin excretion.
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糖尿病大鼠服用奥曲肽：对肾肥大和尿白蛋白排泄的影响。
作者：
A. Flyvbjerg;S. Marshall;J. Frystyk;K. W. Hansen;A. Harris;H. Orskov
实验性糖尿病初期肾脏肥大可通过长效生长抑素类似物奥曲肽（SMS）预防。为了研究SMS对肾肥大和尿白蛋白排泄（UAE）的长期作用，用SMS（100微克× 2）每天两次皮下注射治疗链脲佐菌素糖尿病大鼠和非糖尿病大鼠，持续6个月。未处理的糖尿病和非糖尿病动物用作参照组。两组糖尿病患者的体重、食物摄入量、血糖水平、尿糖排出量、糖化血红蛋白（HbA 1C）、果糖胺、血清生长激素（rGH）或肌酐清除率无差异，但肾脏重量（896 +/- 36 vs. 1000 +/- 24 mg，P <0.02），UAE（417 +/- 131 vs. 1098 +/- 187微克/24小时，P <0.02），肾脏胰岛素样生长因子I（IGF-I）与未治疗的糖尿病组相比，SMS治疗的糖尿病动物的血清IGF-I（167 +/- 16对239 +/- 17 ng/g，P小于0.01）和血清IGF-I（301 +/- 26对407 +/- 17微克/升，P小于0.01）均降低。在非糖尿病大鼠中，SMS降低了体重（274 +/- 3 vs. 293 +/- 5 g，P <0.01），肾脏重量（695 +/- 9 vs. 764 +/- 17 mg，P <0.01），UAE（83 +/- 29 vs. 364 +/- 114微克/24小时，P <0.02），肾脏IGF-I（202 +/- 12 vs. 280 +/- 12 ng/g，P <0.01），血清IGF-I（428 +/- 21 vs. 601 +/- 54微克/升，P小于0.01）和血清rGH（67 +/- 6 vs. 126 +/- 27微克/升，P小于0.05）。当肾脏重量相对于体重表示时，在SMS给药和未给药对照组之间未发现差异，而SMS给药和未给药糖尿病动物之间的差异仍然存在（P <0.01）。总之，SMS的慢性给药对糖尿病肾脏肥大和UAE具有减轻作用，因此表明SMS可以减少实验性糖尿病肾脏病变的发展。SMS对肾肿大和UAE的长期抑制作用可能部分通过降低循环和肾脏IGF-I水平来介导。
Initial renal hypertrophy in experimental diabetes is prevented by administration of a long-acting somatostatin analogue octreotide (SMS). To investigate the long-term effects of SMS on renal hypertrophy and urinary albumin excretion (UAE), streptozotocin-diabetic and non-diabetic rats were treated with two daily subcutaneous injections of SMS (100 micrograms x 2) for six months. Untreated diabetic and non-diabetic animals were used as reference groups. No differences were seen between the two diabetic groups in respect to body weight, food intake, blood glucose levels, urinary glucose output, hemoglobin A1C(HbA1C), fructosamine, serum growth hormone (rGH) or creatinine clearance, but kidney weight (896 +/- 36 vs. 1000 +/- 24 mg, P less than 0.02), UAE (417 +/- 131 vs. 1098 +/- 187 micrograms/24 hr, P less than 0.02), kidney insulin-like growth factor I (IGF-I) (167 +/- 16 vs. 239 +/- 17 ng/g, P less than 0.01) and serum IGF-I (301 +/- 26 vs. 407 +/- 17 micrograms/liter, P less than 0.01) were all reduced in the SMS-treated diabetic animals when compared to the untreated diabetic group. In non-diabetic rats SMS reduced body weight (274 +/- 3 vs. 293 +/- 5 g, P less than 0.01), kidney weight (695 +/- 9 vs. 764 +/- 17 mg, P less than 0.01), UAE (83 +/- 29 vs. 364 +/- 114 micrograms/24 hr, P less than 0.02), kidney IGF-I (202 +/- 12 vs. 280 +/- 12 ng/g, P less than 0.01), serum IGF-I (428 +/- 21 vs. 601 +/- 54 micrograms/liter, P less than 0.01) and serum rGH (67 +/- 6 vs. 126 +/- 27 micrograms/liter, P less than 0.05) when compared to untreated controls. When kidney weights were expressed in relation to body weight no difference was found between SMS-treated and untreated controls, while the difference between SMS-treated and untreated diabetic animals was still present (P less than 0.01). In conclusion, chronic administration of SMS has abating effects on diabetic renal hypertrophy and UAE, and thus indicates that SMS may reduce development of diabetic kidney lesions in experimental diabetes. The long-term suppressive effects of SMS on renal enlargement and UAE may in part be mediated through reduction in circulating and kidney IGF-I levels.
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影响因子：
4.8
作者：
MATHEWS, LS;HAMMER, RE;PALMITER, RD
通讯作者：
PALMITER, RD
大鼠肾小球系膜细胞中胰岛素和 IGF-I 的受体及其作用。
DOI：
10.1152/ajpcell.1988.254.3.c411
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Arnqvist,HJ;Ballermann,BJ;King,GL
通讯作者：
King,GL
大鼠肾小球和肾小管中胰岛素样生长因子 I 的不同受体。
DOI：
10.1152/ajpendo.1988.255.4.e504
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Pillion,DJ;Haskell,JF;Meezan,E
通讯作者：
Meezan,E
DOI：
--
发表时间：
1988
期刊：
The American journal of pathology
影响因子：
--
作者：
T. Doi;L. Striker;C. Quaife;F. Conti;R. Palmiter;R. Behringer;R. Brinster;G. Striker
通讯作者：
T. Doi;L. Striker;C. Quaife;F. Conti;R. Palmiter;R. Behringer;R. Brinster;G. Striker
DOI：
10.1073/pnas.81.3.935
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DERCOLE, AJ;STILES, AD;UNDERWOOD, LE
通讯作者：
UNDERWOOD, LE